Mouse Anti-GM2A Recombinant Antibody (2C8) (V2LY-0226-LY61)

Name: Mouse Anti-GM2A Recombinant Antibody (2C8)
SKU: V2LY-0226-LY61
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

2C8

Application

ELISA

Immunogen

GM2A (aa 94-193) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

GM2 Ganglioside Activator

Entrez Gene ID

2760

UniProt ID

P17900

Function

The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity).

Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3 (By similarity).

Has cholesterol transfer activity (PubMed:17552909).

Biological Process

Ganglioside catabolic process Source: GO_Central
Glycosphingolipid metabolic process Source: Reactome
Learning or memory Source: Ensembl
Lipid storage Source: Ensembl
Lipid transport Source: GO_Central
Neuromuscular process controlling balance Source: Ensembl
Oligosaccharide catabolic process Source: Ensembl
Positive regulation of hydrolase activity Source: Ensembl

Cellular Location

Lysosome

Involvement in disease

GM2-gangliosidosis AB (GM2GAB):
An autosomal recessive lysosomal storage disease marked by the accumulation of GM2 gangliosides in the neuronal cells. It is characterized by GM2 gangliosides accumulation in the presence of both normal hexosaminidase A and B.

PTM

The serines in positions 32 and 33 are absent in 80% of the sequenced protein.

Hsieh, Y. C., Negri, J., He, A., Pearse, R. V., Liu, L., Duong, D. M., ... & Young-Pearse, T. L. (2022). Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity. Molecular neurodegeneration, 17(1), 61.

Xiao, C., Toro, C., & Tifft, C. (2022). GM2 Activator Deficiency. GeneReviews®[Internet].

Kafaei Shahbaz, N. (2022). The Role of GM2 Activator Protein in Breast Cancer Metastasis and the EGFR Signaling Pathway (Doctoral dissertation).

Yuan, J., Li, Z., Lin, Z., Yao, S., Han, Y., Fu, Q., & Liu, J. (2022). Label-free quantitative proteomics reveals the Steap3-Gm2a axis inhibiting the phagosomal escape of Listeria monocytogenes. Microbes and Infection, 24(8), 104999.

Beeler, K., Vowinckel, J., Soste, M., Mallardo, D., Capone, M., Gabriele, M., ... & Ascierto, P. (2020). 229 Discovery of ganglioside GM2 activator as a novel proteomic biomarker associated with response to treatment in first-line melanoma subjects treated with PD-1 immunotherapy.

Holzer, K., Drucker, E., Waldburger, N., Eiteneuer, E., Breuhahn, K., Ori, A., ... & Singer, S. (2018). Ganglioside GM2 activator (GM2A) is as a novel pro-survival p53 target in hepatocellular carcinoma. Zeitschrift für Gastroenterologie, 56(01), A4-44.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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