Human AKR1B1 ELISA Kit (V2LY-0626-LY3802)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.02 ng/mL
Detection Range
0.05-30 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
35.9 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Aldo-Keto Reductase Family 1 Member B
Function
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia (PubMed:1936586). Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:19010934, PubMed:8343525). Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:21329684).
Biological Process
C21-steroid hormone biosynthetic process Source: Reactome
Carbohydrate metabolic process Source: ProtInc
Cellular hyperosmotic salinity response Source: UniProtKB
Cellular response to methylglyoxal Source: Ensembl
Cellular response to peptide Source: Ensembl
Daunorubicin metabolic process Source: UniProtKB
Doxorubicin metabolic process Source: UniProtKB
Epithelial cell maturation Source: Ensembl
Fructose biosynthetic process Source: Reactome
Inner medullary collecting duct development Source: Ensembl
Maternal process involved in female pregnancy Source: Ensembl
Metanephric collecting duct development Source: Ensembl
Naphthalene metabolic process Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Norepinephrine metabolic process Source: Ensembl
Positive regulation of receptor signaling pathway via JAK-STAT Source: Ensembl
Positive regulation of smooth muscle cell proliferation Source: Ensembl
Regulation of urine volume Source: Ensembl
Renal water homeostasis Source: Ensembl
Response to thyroid hormone Source: Ensembl
Response to water deprivation Source: Ensembl
Retinoid metabolic process Source: UniProtKB
Sorbitol biosynthetic process Source: Ensembl
Stress-activated protein kinase signaling cascade Source: Ensembl
Tissue homeostasis Source: Ensembl

Schwab, A., Siddiqui, A., Vazakidou, M. E., Napoli, F., Boettcher, M., Menchicchi, B., ... & Ceppi, P. (2017). Aldo-keto reductase family 1 member b1 links glucose metabolism to epithelial-to-mesenchymal transition.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant AKR1B1 protein, His Tag (CAT#: V2LY-0526-LY1969)

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Isotype control

For research use only. Not intended for any clinical use.

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