Human IKZF3 ELISA Kit (V2LY-0626-LY5438)

Name: Human IKZF3 ELISA Kit
SKU: V2LY-0626-LY5438
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.0073 ng/mL

Detection Range

0.015-3 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

58.0 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

IKAROS family zinc finger 3

Function

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.

Biological Process

B cell activation Source: UniProtKB-KW
Mesoderm development Source: ProtInc
Regulation of apoptotic process Source: UniProtKB
Regulation of B cell differentiation Source: UniProtKB
Regulation of B cell proliferation Source: UniProtKB
Regulation of lymphocyte differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to bacterium Source: Ensembl

Cellular Location

Nucleus; Cytoplasm

PTM

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.

Meng, C., Chen, S., He, Q., Tan, J., Wu, J., & Zhao, J. (2023). IKZF3 modulates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation. International Immunopharmacology, 114, 109480.

Zou, Y., Liu, B., Li, L., Yin, Q., Tang, J., Jing, Z., ... & Chi, T. (2022). IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors. Cancer Letters, 524, 121-130.

Yang, L. K., Lin, C. X., Li, S. H., Liang, J. J., Xiao, L. L., Xie, G. H., ... & Liao, X. (2022). Novel IKZF3 transcriptomic signature correlates with positive outcomes of skin cutaneous melanoma: A pan-cancer analysis. Frontiers in Genetics, 13, 1036402.

Lazarian, G., Yin, S., Ten Hacken, E., Sewastianik, T., Uduman, M., Font-Tello, A., ... & Wu, C. J. (2021). A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer cell, 39(3), 380-393.

Osada, N., Kikuchi, J., Koyama, D., Kuroda, Y., Yasui, H., Leverson, J. D., & Furukawa, Y. (2021). mTOR inhibitors sensitize multiple myeloma cells to venetoclax via IKZF3-and Blimp-1-mediated BCL-2 upregulation. haematologica, 106(11), 3008.

Ridley, M. L., Fleskens, V., Roberts, C. A., Lalnunhlimi, S., Alnesf, A., O’Byrne, A. M., ... & Taams, L. S. (2020). IKZF3/Aiolos is associated with but not sufficient for the expression of IL-10 by CD4+ T cells. The Journal of Immunology, 204(11), 2940-2948.

Vyse, T. J., & Cunninghame Graham, D. S. (2020). Trans-ancestral fine-mapping and epigenetic annotation as tools to delineate functionally relevant risk alleles at IKZF1 and IKZF3 in systemic lupus erythematosus. International Journal of Molecular Sciences, 21(21), 8383.

Dimopoulos, K., Fibiger Munch-Petersen, H., Winther Eskelund, C., Dissing Sjö, L., Ralfkiaer, E., Gimsing, P., & Grønbaek, K. (2019). Expression of CRBN, IKZF1, and IKZF3 does not predict lenalidomide sensitivity and mutations in the cereblon pathway are infrequent in multiple myeloma. Leukemia & lymphoma, 60(1), 180-188.

Awwad, M. H., Kriegsmann, K., Plaumann, J., Benn, M., Hillengass, J., Raab, M. S., ... & Hundemer, M. (2018). The prognostic and predictive value of IKZF1 and IKZF3 expression in T-cells in patients with multiple myeloma. Oncoimmunology, 7(10), e1486356.

Li, L., Ding, X., Wang, X., Yao, Q., Shao, X., An, X., ... & Sun, P. (2018). Polymorphisms of IKZF3 gene and autoimmune thyroid diseases: associated with Graves’ disease but not with Hashimoto’s thyroiditis. Cellular Physiology and Biochemistry, 45(5), 1787-1796.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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