IKZF3

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Full Name
IKAROS family zinc finger 3
Function
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Biological Process
B cell activation Source: UniProtKB-KW
Mesoderm development Source: ProtInc
Regulation of apoptotic process Source: UniProtKB
Regulation of B cell differentiation Source: UniProtKB
Regulation of B cell proliferation Source: UniProtKB
Regulation of lymphocyte differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to bacterium Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
PTM
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.
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Anti-IKZF3 antibodies

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Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I0592) (CBMAB-I1295-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0592
Application*: WB, IH, E
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I0588) (CBMAB-I1291-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0588
Application*: WB, IH, E
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBWJZ-259) (CBMAB-Z0685-WJ)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJZ-259
Application*: E, IF
Datasheet SDS

Rabbit Anti-IKZF3 Recombinant Antibody (EG1629) (CBMAB-EN1950-LY)

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Target: IKZF3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1629
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (1D7) (CBMAB-A10229-LY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1D7
Application*: WB, E
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I2093) (CBMAB-I3263-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2093
Application*: WB, IH
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I1924) (CBMAB-I3094-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1924
Application*: WB
Datasheet SDS

Rabbit Anti-IKZF3 Recombinant Antibody (CBYY-I1828) (CBMAB-I2998-YY)

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Target: IKZF3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-I1828
Application*: WB, P
Datasheet SDS

Rabbit Anti-IKZF3 Recombinant Antibody (CBYY-I1649) (CBMAB-I2819-YY)

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Target: IKZF3
Host: Rabbit
Specificity: Human, Mouse
Clone: CBYY-I1649
Application*: F
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I1257) (CBMAB-I2426-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I1257
Application*: P, WB
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I0954) (CBMAB-I2122-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0954
Application*: P, WB
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I0594) (CBMAB-I1297-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0594
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I0590) (CBMAB-I1293-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0590
Application*: E, LA
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I0589) (CBMAB-I1292-YY)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0589
Application*: E, WB
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (CBYC-A981) (CBMAB-A4478-YC)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A981
Application*: F
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (8B2) (CBMAB-A4477-YC)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 8B2
Application*: WB, F, IP
Datasheet SDS

Mouse Anti-IKZF3 Recombinant Antibody (3H5-G7) (CBMAB-A4476-YC)

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Target: IKZF3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3H5-G7
Application*: WB, IP, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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