Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I1257) (CBMAB-I2426-YY)

Name: Mouse Anti-IKZF3 Recombinant Antibody (CBYY-I1257)
SKU: CBMAB-I2426-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1257

Application

IHC-P, WB

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA, pH 7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

IKAROS family zinc finger 3

Introduction

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.

Entrez Gene ID

22806

UniProt ID

Q9UKT9

Alternative Names

IKAROS Family Zinc Finger 3

Function

Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.

Biological Process

B cell activation Source: UniProtKB-KW
Mesoderm development Source: ProtInc
Regulation of apoptotic process Source: UniProtKB
Regulation of B cell differentiation Source: UniProtKB
Regulation of B cell proliferation Source: UniProtKB
Regulation of lymphocyte differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to bacterium Source: Ensembl

Cellular Location

Nucleus; Cytoplasm

PTM

Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.

Meng, C., Chen, S., He, Q., Tan, J., Wu, J., & Zhao, J. (2023). IKZF3 modulates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation. International Immunopharmacology, 114, 109480.

Zou, Y., Liu, B., Li, L., Yin, Q., Tang, J., Jing, Z., ... & Chi, T. (2022). IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors. Cancer Letters, 524, 121-130.

Yang, L. K., Lin, C. X., Li, S. H., Liang, J. J., Xiao, L. L., Xie, G. H., ... & Liao, X. (2022). Novel IKZF3 transcriptomic signature correlates with positive outcomes of skin cutaneous melanoma: A pan-cancer analysis. Frontiers in Genetics, 13, 1036402.

Lazarian, G., Yin, S., Ten Hacken, E., Sewastianik, T., Uduman, M., Font-Tello, A., ... & Wu, C. J. (2021). A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer cell, 39(3), 380-393.

Osada, N., Kikuchi, J., Koyama, D., Kuroda, Y., Yasui, H., Leverson, J. D., & Furukawa, Y. (2021). mTOR inhibitors sensitize multiple myeloma cells to venetoclax via IKZF3-and Blimp-1-mediated BCL-2 upregulation. haematologica, 106(11), 3008.

Ridley, M. L., Fleskens, V., Roberts, C. A., Lalnunhlimi, S., Alnesf, A., O’Byrne, A. M., ... & Taams, L. S. (2020). IKZF3/Aiolos is associated with but not sufficient for the expression of IL-10 by CD4+ T cells. The Journal of Immunology, 204(11), 2940-2948.

Vyse, T. J., & Cunninghame Graham, D. S. (2020). Trans-ancestral fine-mapping and epigenetic annotation as tools to delineate functionally relevant risk alleles at IKZF1 and IKZF3 in systemic lupus erythematosus. International Journal of Molecular Sciences, 21(21), 8383.

Dimopoulos, K., Fibiger Munch-Petersen, H., Winther Eskelund, C., Dissing Sjö, L., Ralfkiaer, E., Gimsing, P., & Grønbaek, K. (2019). Expression of CRBN, IKZF1, and IKZF3 does not predict lenalidomide sensitivity and mutations in the cereblon pathway are infrequent in multiple myeloma. Leukemia & lymphoma, 60(1), 180-188.

Awwad, M. H., Kriegsmann, K., Plaumann, J., Benn, M., Hillengass, J., Raab, M. S., ... & Hundemer, M. (2018). The prognostic and predictive value of IKZF1 and IKZF3 expression in T-cells in patients with multiple myeloma. Oncoimmunology, 7(10), e1486356.

Li, L., Ding, X., Wang, X., Yao, Q., Shao, X., An, X., ... & Sun, P. (2018). Polymorphisms of IKZF3 gene and autoimmune thyroid diseases: associated with Graves’ disease but not with Hashimoto’s thyroiditis. Cellular Physiology and Biochemistry, 45(5), 1787-1796.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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For research use only. Not intended for any clinical use.

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