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Mouse Anti-IKZF3 Recombinant Antibody (3H5-G7) (CBMAB-A4476-YC)

Provided herein is a Mouse monoclonal antibody against Human IKAROS Family Zinc Finger 3. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all IKZF3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3H5-G7
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
IKAROS family zinc finger 3
Introduction
IKZF3 is a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a
Entrez Gene ID
22806
UniProt ID
Q9UKT9
Alternative Names
AIO; AIOLOS; ZNFN1A3
Function
Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner.
Biological Process
B cell activation Source: UniProtKB-KW
Mesoderm development Source: ProtInc
Regulation of apoptotic process Source: UniProtKB
Regulation of B cell differentiation Source: UniProtKB
Regulation of B cell proliferation Source: UniProtKB
Regulation of lymphocyte differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Response to bacterium Source: Ensembl
Cellular Location
Nucleus; Cytoplasm
PTM
Phosphorylation on tyrosine residues induced by IL2 is required for dissociation from HRAS and nuclear translocation of IKZF3 in T-cells. Phosphorylation on tyrosine residues induced by IL4 is required for dissociation from Bcl-X(L) in T-cells.

Meng, C., Chen, S., He, Q., Tan, J., Wu, J., & Zhao, J. (2023). IKZF3 modulates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation. International Immunopharmacology, 114, 109480.

Zou, Y., Liu, B., Li, L., Yin, Q., Tang, J., Jing, Z., ... & Chi, T. (2022). IKZF3 deficiency potentiates chimeric antigen receptor T cells targeting solid tumors. Cancer Letters, 524, 121-130.

Yang, L. K., Lin, C. X., Li, S. H., Liang, J. J., Xiao, L. L., Xie, G. H., ... & Liao, X. (2022). Novel IKZF3 transcriptomic signature correlates with positive outcomes of skin cutaneous melanoma: A pan-cancer analysis. Frontiers in Genetics, 13, 1036402.

Lazarian, G., Yin, S., Ten Hacken, E., Sewastianik, T., Uduman, M., Font-Tello, A., ... & Wu, C. J. (2021). A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer cell, 39(3), 380-393.

Osada, N., Kikuchi, J., Koyama, D., Kuroda, Y., Yasui, H., Leverson, J. D., & Furukawa, Y. (2021). mTOR inhibitors sensitize multiple myeloma cells to venetoclax via IKZF3-and Blimp-1-mediated BCL-2 upregulation. haematologica, 106(11), 3008.

Ridley, M. L., Fleskens, V., Roberts, C. A., Lalnunhlimi, S., Alnesf, A., O’Byrne, A. M., ... & Taams, L. S. (2020). IKZF3/Aiolos is associated with but not sufficient for the expression of IL-10 by CD4+ T cells. The Journal of Immunology, 204(11), 2940-2948.

Vyse, T. J., & Cunninghame Graham, D. S. (2020). Trans-ancestral fine-mapping and epigenetic annotation as tools to delineate functionally relevant risk alleles at IKZF1 and IKZF3 in systemic lupus erythematosus. International Journal of Molecular Sciences, 21(21), 8383.

Dimopoulos, K., Fibiger Munch-Petersen, H., Winther Eskelund, C., Dissing Sjö, L., Ralfkiaer, E., Gimsing, P., & Grønbaek, K. (2019). Expression of CRBN, IKZF1, and IKZF3 does not predict lenalidomide sensitivity and mutations in the cereblon pathway are infrequent in multiple myeloma. Leukemia & lymphoma, 60(1), 180-188.

Awwad, M. H., Kriegsmann, K., Plaumann, J., Benn, M., Hillengass, J., Raab, M. S., ... & Hundemer, M. (2018). The prognostic and predictive value of IKZF1 and IKZF3 expression in T-cells in patients with multiple myeloma. Oncoimmunology, 7(10), e1486356.

Li, L., Ding, X., Wang, X., Yao, Q., Shao, X., An, X., ... & Sun, P. (2018). Polymorphisms of IKZF3 gene and autoimmune thyroid diseases: associated with Graves’ disease but not with Hashimoto’s thyroiditis. Cellular Physiology and Biochemistry, 45(5), 1787-1796.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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