Human IL36G ELISA Kit (V2LY-0626-LY4150)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.017 ng/mL
Detection Range
0.03-9 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
18.7 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Interleukin 36 Gamma
Function
Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous proinflammatory parameters TNF-alpha, S100A7/psoriasin and inducible NOS. May play a role in proinflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus.
Biological Process
Cell-cell signalingManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIBA:GO_Central
Innate immune responseIEA:UniProtKB-KW
Positive regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm; Secreted. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion.
PTM
N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold) (PubMed:21965679).
Proteolytically cleaved by cathepsin CTSG (PubMed:30804664).

Moreira, C. R., de Alcântara, C. C., Flauzino, T., Martin, L. M. M., Lozovoy, M. A. B., Reiche, E. M. V., & Simão, A. N. C. (2023). IL36G genetic variant is independently associated with susceptibility, severity and joint involvement in psoriasis. Molecular Immunology, 159, 69-75.

Merleev, A., Ji-Xu, A., Toussi, A., Tsoi, L. C., Le, S. T., Luxardi, G., ... & Maverakis, E. (2022). Proprotein convertase subtilisin/kexin type 9 is a psoriasis-susceptibility locus that is negatively related to IL36G. JCI insight, 7(16).

Lu, Y. W., Chen, Y. J., Shi, N., Yang, L. H., Wang, H. M., Dong, R. J., ... & Li, Y. Y. (2022). IL36G is associated with cutaneous antiviral competence in psoriasis. Frontiers in Immunology, 13, 971071.

Furue, K., Ito, T., Tanaka, Y., Yumine, A., Hashimoto-Hachiya, A., Takemura, M., ... & Furue, M. (2019). Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon. Journal of dermatological science, 94(1), 244-251.

Traks, T., Keermann, M., Prans, E., Karelson, M., Loite, U., Kõks, G., ... & Kingo, K. (2019). Polymorphisms in IL36G gene are associated with plaque psoriasis. BMC Medical Genetics, 20, 1-8.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL36G protein (CAT#: V2LY-0526-LY4908)

Human Recombinant IL36G protein-1 (CAT#: V2LY-0526-LY4909)

Human Recombinant IL36G protein, His Tag (CAT#: V2LY-0526-LY4910)

Mouse Recombinant IL36G protein, His Tag (CAT#: V2LY-0526-LY8541)

Related Products

Mouse Anti-IL36G Recombinant Antibody (CBYY-I1989) (CAT#: CBMAB-I3159-YY)

Human Recombinant IL36G protein-1 (CAT#: V2LY-0526-LY4909)

Mouse Anti-IL36G Recombinant Antibody (CBYY-I1106) (CAT#: CBMAB-I2274-YY)

Mouse Anti-IL36G Recombinant Antibody (2A8) (CAT#: CBMAB-A4376-LY)

Rat Anti-IL36G Recombinant Antibody (CBYY-I0212) (CAT#: CBMAB-I0562-YY)

Mouse Anti-IL36G Recombinant Antibody (CBYY-I2118) (CAT#: CBMAB-I3288-YY)

Human Recombinant IL36G protein, His Tag (CAT#: V2LY-0526-LY4910)

Mouse Anti-IL36G Recombinant Antibody (2F4) (CAT#: CBMAB-I0563-YY)

Human Recombinant IL36G protein (CAT#: V2LY-0526-LY4908)

Rat Anti-IL36G Recombinant Antibody (A563) (CAT#: CBMAB-AP3927LY)

Isotype control

For research use only. Not intended for any clinical use.

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