Human OPTC ELISA Kit (V2LY-0626-LY5584)

Name: Human OPTC ELISA Kit
SKU: V2LY-0626-LY5584
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.17 ng/mL

Detection Range

0.3-90 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

37.3 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Opticin

Function

Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity).
Binds collagen fibrils (By similarity).
May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).

Biological Process

Collagen fibril organizationISS:UniProtKB

PTM

O-glycosylated.
Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380).
Proteolytically cleaved by MMP13 (By similarity).
The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380).By Similarity1 Publication
Sulfated on tyrosine residues.

Freiberg, J., Welikala, R. A., Rovelt, J., Owen, C. G., Rudnicka, A. R., Kolko, M., ... & FOREVER consortium. (2023). Automated analysis of vessel morphometry in retinal images from a Danish high street optician setting. Plos one, 18(8), e0290278.

Liu, X., Xing, Y., Liu, X., Zeng, L., & Ma, J. (2022). Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain–Collagen Complex Formation and RhoA/ROCK1 Signaling. Investigative Ophthalmology & Visual Science, 63(1), 13-13.

Patnaik, S., Rai, M., Jalali, S., Agarwal, K., Badakere, A., Puppala, L., ... & Kaur, I. (2021). An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina. Scientific reports, 11(1), 7444.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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