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Rat Anti-OPTC (AA 20-232) Recombinant Antibody (CBXO-0281) (CBMAB-O0494-CQ)

This product is a rat antibody that recognizes OPTC (AA 20-232). The antibody CBXO-0281 can be used for immunoassay techniques such as: ELISA, WB.
See all OPTC antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBXO-0281
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
NS0-derived recombinant human Opticin (aa20-332) Accession #Q9UBM4
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 20-232

Target

Full Name
Opticin
Introduction
Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).
Entrez Gene ID
26254
UniProt ID
Q9UBM4
Alternative Names
Opticin; Oculoglycan; OPT
Function
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity).
Binds collagen fibrils (By similarity).
May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
Biological Process
Collagen fibril organizationISS:UniProtKB
PTM
O-glycosylated.
Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380).
Proteolytically cleaved by MMP13 (By similarity).
The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380).By Similarity1 Publication
Sulfated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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