Rat Anti-OPTC (AA 20-232) Recombinant Antibody (CBXO-0281) (CBMAB-O0494-CQ)

Name: Rat Anti-OPTC (AA 20-232) Recombinant Antibody (CBXO-0281)
SKU: CBMAB-O0494-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

CBXO-0281

Application

ELISA, WB

Immunogen

NS0-derived recombinant human Opticin (aa20-332) Accession #Q9UBM4

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

AA 20-232

More Infomation

Target

Full Name

Opticin

Introduction

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).

Entrez Gene ID

26254

UniProt ID

Q9UBM4

Alternative Names

Opticin; Oculoglycan; OPT

Function

Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity).
Binds collagen fibrils (By similarity).
May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).

Biological Process

Collagen fibril organizationISS:UniProtKB

PTM

O-glycosylated.
Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380).
Proteolytically cleaved by MMP13 (By similarity).
The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380).By Similarity1 Publication
Sulfated on tyrosine residues.

Freiberg, J., Welikala, R. A., Rovelt, J., Owen, C. G., Rudnicka, A. R., Kolko, M., ... & FOREVER consortium. (2023). Automated analysis of vessel morphometry in retinal images from a Danish high street optician setting. Plos one, 18(8), e0290278.

Liu, X., Xing, Y., Liu, X., Zeng, L., & Ma, J. (2022). Opticin Ameliorates Hypoxia-Induced Retinal Angiogenesis by Suppression of Integrin α2-I Domain–Collagen Complex Formation and RhoA/ROCK1 Signaling. Investigative Ophthalmology & Visual Science, 63(1), 13-13.

Patnaik, S., Rai, M., Jalali, S., Agarwal, K., Badakere, A., Puppala, L., ... & Kaur, I. (2021). An interplay of microglia and matrix metalloproteinase MMP9 under hypoxic stress regulates the opticin expression in retina. Scientific reports, 11(1), 7444.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rat Anti-OPTC (AA 20-332) Recombinant Antibody (CBXO-0383) (CAT#: CBMAB-O0495-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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