OPTC

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).
Full Name
Opticin
Function
Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity).
Binds collagen fibrils (By similarity).
May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).
Biological Process
Collagen fibril organizationISS:UniProtKB
PTM
O-glycosylated.
Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380).
Proteolytically cleaved by MMP13 (By similarity).
The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380).By Similarity1 Publication
Sulfated on tyrosine residues.
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Anti-OPTC antibodies

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Rat Anti-OPTC (AA 20-332) Recombinant Antibody (CBXO-0383) (CBMAB-O0495-CQ)

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Target: OPTC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0383
Application*: WB
Datasheet SDS

Rat Anti-OPTC (AA 20-232) Recombinant Antibody (CBXO-0281) (CBMAB-O0494-CQ)

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Target: OPTC
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0281
Application*: E, WB
Datasheet SDS

Human OPTC ELISA Kit (V2LY-0626-LY5584)

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Target: OPTC
Sensitivity: 0.17 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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