OPTC

Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1).

Full Name

Opticin

Function

Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity).
Binds collagen fibrils (By similarity).
May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity).

Biological Process

Collagen fibril organizationISS:UniProtKB

PTM

O-glycosylated.
Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380).
Proteolytically cleaved by MMP13 (By similarity).
The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380).By Similarity1 Publication
Sulfated on tyrosine residues.