Human PHGDH ELISA Kit (V2LY-0626-LY2395)

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Tested Data
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Basic Information

Sensitivity
0.021 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
56.7 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Phosphoglycerate Dehydrogenase
Function
Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate.
Biological Process
Brain developmentManual Assertion Based On ExperimentTAS:ProtInc
G1 to G0 transitionIEA:Ensembl
Gamma-aminobutyric acid metabolic processIEA:Ensembl
Glial cell developmentIEA:Ensembl
Glutamine metabolic processIEA:Ensembl
Glycine metabolic processIEA:Ensembl
L-serine biosynthetic processIEA:UniProtKB-KW
Neural tube developmentIEA:Ensembl
Neuron projection developmentIEA:Ensembl
Regulation of gene expressionIEA:Ensembl
Spinal cord developmentIEA:Ensembl
Taurine metabolic processIEA:Ensembl
Threonine metabolic processIEA:Ensembl
Cellular Location
cytosol
extracellular exosome
Involvement in disease
Phosphoglycerate dehydrogenase deficiency (PHGDHD):
An autosomal recessive inborn error of L-serine biosynthesis, clinically characterized by congenital microcephaly, psychomotor retardation, and seizures.
Neu-Laxova syndrome 1 (NLS1):
A lethal, autosomal recessive multiple malformation syndrome characterized by ichthyosis, marked intrauterine growth restriction, microcephaly, short neck, limb deformities, hypoplastic lungs, edema, and central nervous system anomalies including lissencephaly, cerebellar hypoplasia and/or abnormal/agenesis of the corpus callosum. Abnormal facial features include severe proptosis with ectropion, hypertelorism, micrognathia, flattened nose, and malformed ears.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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