Human Recombinant ACTR2 protein, GST Tag (V2LY-0526-LY1907)

Name: Human Recombinant ACTR2 protein, GST Tag
SKU: V2LY-0526-LY1907
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant ACTR2 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 70 kDa.

Molecule Mass

70 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Actinin Alpha 2

Function

ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).

Biological Process

Arp2/3 complex-mediated actin nucleation
Associative learning
Asymmetric cell division
Cellular response to interferon-gamma
Cellular response to trichostatin A
Cilium assembly
Cytosolic transport
Ephrin receptor signaling pathway
Establishment or maintenance of cell polarity
Fc-gamma receptor signaling pathway involved in phagocytosis
Meiotic chromosome movement towards spindle pole
Meiotic cytokinesis
Membrane organization
Neutrophil degranulation
Positive regulation of dendritic spine morphogenesis
Positive regulation of double-strand break repair via homologous recombination
Positive regulation of lamellipodium assembly
Positive regulation of transcription by RNA polymerase II
Response to ethanol
Response to immobilization stress
Spindle localization

Cellular Location

Nucleus; Cytoskeleton; Cell projection

Yun, J., Ren, J., Liu, Y., Dai, L., Song, L., Ma, X., ... & Song, Y. (2021). Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy. Diabetology & Metabolic Syndrome, 13(1), 1-12.

Siebert, A. E., Hobbs, L. M., Johnston, A. J., Mishack, L. M., Brake, M. A., Cleuren, A., ... & Westrick, R. J. (2017). A Missense Mutation in the Loss-of-Function Intolerant Actr2 Gene Suppresses Thrombosis Via Multiple Mechanisms. Blood, 130(Supplement 1), 1058-1058.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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