Human Recombinant ACVR2A , Active protein, His Tag (V2LY-0526-LY1923)

Name: Human Recombinant ACVR2A , Active protein, His Tag
SKU: V2LY-0526-LY1923
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ACVR2A , Active protein, His Tag consist of Amino Acid: 161-end and predicts a molecular mass of 47 kDa.

Molecule Mass

47 kDa

Sequence

Amino Acid: 161-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tirs, NaCl, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

ACTIVIN A RECEPTOR TYPE 2A

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).

Biological Process

Activin receptor signaling pathway
Anterior/posterior pattern specification
BMP signaling pathway
Cellular response to BMP stimulus
Cellular response to growth factor stimulus
Determination of left/right symmetry
Embryonic skeletal system development
Gastrulation with mouth forming second
Mesoderm development
Negative regulation of BMP signaling pathway
Penile erection
Positive regulation of activin receptor signaling pathway
Positive regulation of BMP signaling pathway
Positive regulation of bone mineralization
Positive regulation of erythrocyte differentiation
Positive regulation of osteoblast differentiation
Positive regulation of pathway-restricted SMAD protein phosphorylation
Positive regulation of protein phosphorylation
Positive regulation of transcription by RNA polymerase II
Protein phosphorylation
Regulation of nitric-oxide synthase activity
Sertoli cell proliferation
Spermatogenesis
Sperm ejaculation
Transmembrane receptor protein serine/threonine kinase signaling pathway

Cellular Location

Membrane

Topology

Extracellular: 20-135 aa
Helical: 136-161 aa
Cytoplasmic: 162-513 aa

Yuza, K., Nagahashi, M., Ichikawa, H., Hanyu, T., Nakajima, M., Shimada, Y., ... & Wakai, T. (2021). Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-11.

Monsivais, D., Nagashima, T., Prunskaite-Hyyryläinen, R., Nozawa, K., Shimada, K., Tang, S., ... & Matzuk, M. M. (2021). Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. Nature communications, 12(1), 1-17.

Zhang, B., Liang, T., & Ru, G. (2021). Letter to the Editor: Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-2.

Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brûlé, E., ... & Bernard, D. J. (2020). Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B. Endocrinology, 161(7).

Bhattacharya, T. K., Shukla, R., Chatterjee, R. N., & Bhanja, S. K. (2019). Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Scientific reports, 9(1), 1-13.

Zhuo, C., Hu, D., Lin, X., Chen, Y., Zheng, X., & Yang, C. (2018). Down expression of activin A receptor type 2A in relation to metastatic potential and prognosis of patients with colon cancer.

Zhang, H., Ju, B., Nie, Y., Song, B., Xu, Y., & Gao, P. (2018). Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells. International journal of molecular medicine, 42(1), 279-289.

Zhuo, C., Hu, D., Li, J., Yu, H., Lin, X., Chen, Y., ... & Yang, C. (2018). Downregulation of activin a receptor type 2A is associated with metastatic potential and poor prognosis of colon cancer. Journal of Cancer, 9(19), 3626.

Goh, B. C., Singhal, V., Herrera, A. J., Tomlinson, R. E., Kim, S., Faugere, M. C., ... & DiGirolamo, D. J. (2017). Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. Journal of Biological Chemistry, 292(33), 13809-13822.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ACVR2A protein, hFc Tag (CAT#: V2LY-0526-LY1921)

Human Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY1922)

Human Recombinant ACVR2A protein, His Tag-1 (CAT#: V2LY-0526-LY1924)

Mouse Recombinant ACVR2A protein, His & hFc Tag (CAT#: V2LY-0526-LY7775)

Mouse Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY7776)

Mouse Recombinant ACVR2A protein, Fc Tag (CAT#: V2LY-0526-LY7777)

Rabbit Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY9117)

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Mouse Recombinant ACVR2A protein, His & hFc Tag (CAT#: V2LY-0526-LY7775)

Mouse Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY7776)

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Mouse Recombinant ACVR2A protein, Fc Tag (CAT#: V2LY-0526-LY7777)

Human Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY1922)

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Mouse Anti-ACVR2A Recombinant Antibody (V2-179691) (CAT#: CBMAB-A1049-YC)

Human Recombinant ACVR2A protein, hFc Tag (CAT#: V2LY-0526-LY1921)

Human Recombinant ACVR2A protein, His Tag-1 (CAT#: V2LY-0526-LY1924)

Isotype control

For research use only. Not intended for any clinical use.

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