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ACVR2A

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene.
Full Name
ACTIVIN A RECEPTOR TYPE 2A
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).
Biological Process
Activin receptor signaling pathway
Anterior/posterior pattern specification
BMP signaling pathway
Cellular response to BMP stimulus
Cellular response to growth factor stimulus
Determination of left/right symmetry
Embryonic skeletal system development
Gastrulation with mouth forming second
Mesoderm development
Negative regulation of BMP signaling pathway
Penile erection
Positive regulation of activin receptor signaling pathway
Positive regulation of BMP signaling pathway
Positive regulation of bone mineralization
Positive regulation of erythrocyte differentiation
Positive regulation of osteoblast differentiation
Positive regulation of pathway-restricted SMAD protein phosphorylation
Positive regulation of protein phosphorylation
Positive regulation of transcription by RNA polymerase II
Protein phosphorylation
Regulation of nitric-oxide synthase activity
Sertoli cell proliferation
Spermatogenesis
Sperm ejaculation
Transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Location
Membrane
Topology
Extracellular: 20-135 aa
Helical: 136-161 aa
Cytoplasmic: 162-513 aa

Anti-ACVR2A antibodies

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Target: ACVR2A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-12517
Application*: WB, IH
Target: ACVR2A
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: V2-12518
Application*: WB, IH
Target: ACVR2A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: V2-179689
Application*: IP, WB
Target: ACVR2A
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179690
Application*: WB
Target: ACVR2A
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-179691
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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