Mouse Recombinant ACVR2A protein, His & hFc Tag (V2LY-0526-LY7775)

Name: Mouse Recombinant ACVR2A protein, His & hFc Tag
SKU: V2LY-0526-LY7775
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His & hFc Tag

Protein Construction

This product is Mouse Recombinant ACVR2A protein, His & hFc Tag consist of Amino Acid: 1-134 and predicts a molecular mass of 41.4 kDa.

Molecule Mass

41.4 kDa

Sequence

Amino Acid: 1-134

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

ACTIVIN A RECEPTOR TYPE 2A

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (By similarity).

Biological Process

Activin receptor signaling pathway
Anterior/posterior pattern specification
BMP signaling pathway
Cellular response to BMP stimulus
Cellular response to growth factor stimulus
Determination of left/right symmetry
Embryonic skeletal system development
Gastrulation with mouth forming second
Mesoderm development
Negative regulation of BMP signaling pathway
Penile erection
Positive regulation of activin receptor signaling pathway
Positive regulation of BMP signaling pathway
Positive regulation of bone mineralization
Positive regulation of erythrocyte differentiation
Positive regulation of osteoblast differentiation
Positive regulation of pathway-restricted SMAD protein phosphorylation
Positive regulation of protein phosphorylation
Positive regulation of transcription by RNA polymerase II
Protein phosphorylation
Regulation of nitric-oxide synthase activity
Sertoli cell proliferation
Spermatogenesis
Sperm ejaculation
Transmembrane receptor protein serine/threonine kinase signaling pathway

Cellular Location

Membrane

Topology

Extracellular: 20-135 aa
Helical: 136-161 aa
Cytoplasmic: 162-513 aa

Yuza, K., Nagahashi, M., Ichikawa, H., Hanyu, T., Nakajima, M., Shimada, Y., ... & Wakai, T. (2021). Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-11.

Monsivais, D., Nagashima, T., Prunskaite-Hyyryläinen, R., Nozawa, K., Shimada, K., Tang, S., ... & Matzuk, M. M. (2021). Endometrial receptivity and implantation require uterine BMP signaling through an ACVR2A-SMAD1/SMAD5 axis. Nature communications, 12(1), 1-17.

Zhang, B., Liang, T., & Ru, G. (2021). Letter to the Editor: Activin a Receptor Type 2A Mutation Affects the Tumor Biology of Microsatellite Instability-High Gastric Cancer. Journal of Gastrointestinal Surgery, 1-2.

Schang, G., Ongaro, L., Schultz, H., Wang, Y., Zhou, X., Brûlé, E., ... & Bernard, D. J. (2020). Murine FSH production depends on the activin type II receptors ACVR2A and ACVR2B. Endocrinology, 161(7).

Bhattacharya, T. K., Shukla, R., Chatterjee, R. N., & Bhanja, S. K. (2019). Comparative analysis of silencing expression of myostatin (MSTN) and its two receptors (ACVR2A and ACVR2B) genes affecting growth traits in knock down chicken. Scientific reports, 9(1), 1-13.

Zhuo, C., Hu, D., Lin, X., Chen, Y., Zheng, X., & Yang, C. (2018). Down expression of activin A receptor type 2A in relation to metastatic potential and prognosis of patients with colon cancer.

Zhang, H., Ju, B., Nie, Y., Song, B., Xu, Y., & Gao, P. (2018). Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells. International journal of molecular medicine, 42(1), 279-289.

Zhuo, C., Hu, D., Li, J., Yu, H., Lin, X., Chen, Y., ... & Yang, C. (2018). Downregulation of activin a receptor type 2A is associated with metastatic potential and poor prognosis of colon cancer. Journal of Cancer, 9(19), 3626.

Goh, B. C., Singhal, V., Herrera, A. J., Tomlinson, R. E., Kim, S., Faugere, M. C., ... & DiGirolamo, D. J. (2017). Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. Journal of Biological Chemistry, 292(33), 13809-13822.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ACVR2A protein, hFc Tag (CAT#: V2LY-0526-LY1921)

Human Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY1922)

Human Recombinant ACVR2A , Active protein, His Tag (CAT#: V2LY-0526-LY1923)

Human Recombinant ACVR2A protein, His Tag-1 (CAT#: V2LY-0526-LY1924)

Mouse Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY7776)

Mouse Recombinant ACVR2A protein, Fc Tag (CAT#: V2LY-0526-LY7777)

Rabbit Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY9117)

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Human Recombinant ACVR2A , Active protein, His Tag (CAT#: V2LY-0526-LY1923)

Mouse Recombinant ACVR2A protein, Fc Tag (CAT#: V2LY-0526-LY7777)

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Human Recombinant ACVR2A protein, hFc Tag (CAT#: V2LY-0526-LY1921)

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Rabbit Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY9117)

Human Recombinant ACVR2A protein, His Tag-1 (CAT#: V2LY-0526-LY1924)

Mouse Recombinant ACVR2A protein, His Tag (CAT#: V2LY-0526-LY7776)

Mouse Anti-ACVR2A Recombinant Antibody (V2-179690) (CAT#: CBMAB-A1048-YC)

Isotype control

For research use only. Not intended for any clinical use.

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