Human Recombinant ACY1 protein, His Tag (V2LY-0526-LY2075)

Name: Human Recombinant ACY1 protein, His Tag
SKU: V2LY-0526-LY2075
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ACY1 protein, His Tag consist of Amino Acid: 1-408 and predicts a molecular mass of 47.3 kDa.

Molecule Mass

47.3 kDa

Sequence

Amino Acid: 1-408

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Aminoacylase 1

Function

Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).

Biological Process

Aflatoxin metabolic process
Cellular amino acid metabolic process

Cellular Location

Cytoplasm

Involvement in disease

Aminoacylase-1 deficiency (ACY1D): An enzymatic deficiency resulting in encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.

Chen, Z., Gao, J., Sun, J., Wu, Z., & Wang, B. (2021). Aminoacylase 1 (ACY-1) Mediates the Proliferation and Migration of Neuroblastoma Cells in Humans Through the ERK/Transforming Growth Factor β (TGF-β) Signaling Pathways. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e928813-1.

Al-Helaly, L. A., & Mahmood, E. S. (2021). Biochemical and Histological Study of Aminoacylase-1 Purified from Amniotic Fluid in Rats with Oxidative Stress Induced by Lead Acetate. Baghdad Science Journal, 18(3), 0583-0583.

Xu, Z., Hu, Y., & Yu, Z. (2021). Effect of the ACY‑1 gene on HER2 and TRAIL expression in rectal carcinoma. Experimental and Therapeutic Medicine, 22(2), 1-7.

Wang, G., Li, H., & Hou, Y. (2021). LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma. Cancer Gene Therapy, 1-12.

Balamurugan, T. S. T., Huang, C. H., Chang, P. C., & Huang, S. T. (2018). Electrochemical molecular switch for the selective profiling of cysteine in live cells and whole blood and for the quantification of aminoacylase-1. Analytical chemistry, 90(21), 12631-12638.

Cheng, Q., Gu, S., Liu, Z., Wang, C. Z., & Li, X. (2017). Expressional divergence of the fatty acid-amino acid conjugate-hydrolyzing aminoacylase 1 (L-ACY-1) in Helicoverpa armigera and Helicoverpa assulta. Scientific reports, 7(1), 1-11.

Yu, B., Liu, X., Cao, X., Zhang, M., & Chang, H. (2017). Study of the expression and function of ACY1 in patients with colorectal cancer. Oncology letters, 13(4), 2459-2464.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

ACY1 Matched Antibody Pair (020) (CAT#: APMAB-020LY)

ACY1 Matched Antibody Pair (021) (CAT#: APMAB-021LY)

ACY1 Matched Antibody Pair (022) (CAT#: APMAB-022LY)

Mouse Recombinant ACY1 protein, His Tag (CAT#: V2LY-0526-LY7801)

Antibody Pairs

ACY1 Matched Antibody Pair (020) (CAT#: APMAB-020LY)

ACY1 Matched Antibody Pair (021) (CAT#: APMAB-021LY)

ACY1 Matched Antibody Pair (022) (CAT#: APMAB-022LY)

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ACY1 Matched Antibody Pair (022) (CAT#: APMAB-022LY)

ACY1 Matched Antibody Pair (020) (CAT#: APMAB-020LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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