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ACY1

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
Full Name
Aminoacylase 1
Function
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Biological Process
Aflatoxin metabolic process
Cellular amino acid metabolic process
Cellular Location
Cytoplasm
Involvement in disease
Aminoacylase-1 deficiency (ACY1D): An enzymatic deficiency resulting in encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.
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Anti-ACY1 antibodies

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Mouse Anti-ACY1 Recombinant Antibody (V2-179710) (CBMAB-A1070-YC)

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Target: ACY1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Mouse
Clone: V2-179710
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-ACY1 Recombinant Antibody (V2-610974) (CBMAB-A0117-LY)

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Target: ACY1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: V2-610974
Application*: WB, E, IP
Datasheet SDS

Rabbit Anti-ACY1 Recombinant Antibody (V2-179726) (CBMAB-A1086-YC)

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Target: ACY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-179726
Application*: F, IC, IF
Datasheet SDS

Mouse Anti-ACY1 Recombinant Antibody (V2-179725) (CBMAB-A1085-YC)

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Target: ACY1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179725
Application*: P
Datasheet SDS

Rat Anti-ACY1 Recombinant Antibody (V2-179722) (CBMAB-A1082-YC)

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Target: ACY1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: V2-179722
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-ACY1 Recombinant Antibody (V2-179721) (CBMAB-A1081-YC)

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Target: ACY1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179721
Application*: E, WB
Datasheet SDS

Mouse Anti-ACY1 Recombinant Antibody (V2-179719) (CBMAB-A1079-YC)

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Target: ACY1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179719
Application*: E, IC, IF, IP, P, WB
Datasheet SDS

Mouse Anti-ACY1 Recombinant Antibody (V2-179714) (CBMAB-A1074-YC)

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Target: ACY1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: V2-179714
Application*: E, WB
Datasheet SDS

Mouse Anti-ACY1 Recombinant Antibody (V2-179708) (CBMAB-A1068-YC)

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Target: ACY1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-179708
Application*: F, IH, WB
Datasheet SDS

Rabbit Anti-ACY1 Recombinant Antibody (V2-179707) (CBMAB-A1067-YC)

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Target: ACY1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: V2-179707
Application*: P
Datasheet SDS

ACY1 Matched Antibody Pair (022) (APMAB-022LY)

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Target: ACY1
Specificity: Human
Datasheet SDS

ACY1 Matched Antibody Pair (021) (APMAB-021LY)

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Target: ACY1
Specificity: Human
Datasheet SDS

ACY1 Matched Antibody Pair (020) (APMAB-020LY)

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Target: ACY1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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