Mouse Anti-ACY1 Recombinant Antibody (V2-610974) (CBMAB-A0117-LY)

Name: Mouse Anti-ACY1 Recombinant Antibody (V2-610974)
SKU: CBMAB-A0117-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

V2-610974

Application

WB, ELISA, IP

Immunogen

ACY1 (AAH00545, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH7.4

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Aminoacylase 1

Introduction

Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes. [provided by RefSeq]

Entrez Gene ID

Alternative Names

ACY1D; ACYLASE

Function

Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).

Biological Process

Aflatoxin metabolic process
Cellular amino acid metabolic process

Cellular Location

Cytoplasm

Involvement in disease

Aminoacylase-1 deficiency (ACY1D): An enzymatic deficiency resulting in encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.

Chen, Z., Gao, J., Sun, J., Wu, Z., & Wang, B. (2021). Aminoacylase 1 (ACY-1) Mediates the Proliferation and Migration of Neuroblastoma Cells in Humans Through the ERK/Transforming Growth Factor β (TGF-β) Signaling Pathways. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e928813-1.

Al-Helaly, L. A., & Mahmood, E. S. (2021). Biochemical and Histological Study of Aminoacylase-1 Purified from Amniotic Fluid in Rats with Oxidative Stress Induced by Lead Acetate. Baghdad Science Journal, 18(3), 0583-0583.

Xu, Z., Hu, Y., & Yu, Z. (2021). Effect of the ACY‑1 gene on HER2 and TRAIL expression in rectal carcinoma. Experimental and Therapeutic Medicine, 22(2), 1-7.

Wang, G., Li, H., & Hou, Y. (2021). LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma. Cancer Gene Therapy, 1-12.

Balamurugan, T. S. T., Huang, C. H., Chang, P. C., & Huang, S. T. (2018). Electrochemical molecular switch for the selective profiling of cysteine in live cells and whole blood and for the quantification of aminoacylase-1. Analytical chemistry, 90(21), 12631-12638.

Cheng, Q., Gu, S., Liu, Z., Wang, C. Z., & Li, X. (2017). Expressional divergence of the fatty acid-amino acid conjugate-hydrolyzing aminoacylase 1 (L-ACY-1) in Helicoverpa armigera and Helicoverpa assulta. Scientific reports, 7(1), 1-11.

Yu, B., Liu, X., Cao, X., Zhang, M., & Chang, H. (2017). Study of the expression and function of ACY1 in patients with colorectal cancer. Oncology letters, 13(4), 2459-2464.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

ACY1 Matched Antibody Pair (020) (CAT#: APMAB-020LY)

ACY1 Matched Antibody Pair (021) (CAT#: APMAB-021LY)

ACY1 Matched Antibody Pair (022) (CAT#: APMAB-022LY)

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Mouse Anti-ACY1 Recombinant Antibody (V2-179708) (CAT#: CBMAB-A1068-YC)

ACY1 Matched Antibody Pair (022) (CAT#: APMAB-022LY)

Mouse Anti-ACY1 Recombinant Antibody (V2-179725) (CAT#: CBMAB-A1085-YC)

Rat Anti-ACY1 Recombinant Antibody (V2-179722) (CAT#: CBMAB-A1082-YC)

Mouse Anti-ACY1 Recombinant Antibody (V2-179719) (CAT#: CBMAB-A1079-YC)

Mouse Anti-ACY1 Recombinant Antibody (V2-179721) (CAT#: CBMAB-A1081-YC)

ACY1 Matched Antibody Pair (021) (CAT#: APMAB-021LY)

ACY1 Matched Antibody Pair (020) (CAT#: APMAB-020LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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