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Mouse Anti-ACY1 Recombinant Antibody (V2-610974) (CBMAB-A0117-LY)

The product is antibody recognizes ACY1. The antibody 1A11-F6 immunoassay techniques such as: WB, ELISA.
See all ACY1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-610974
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IP

Basic Information

Immunogen
ACY1 (AAH00545, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Aminoacylase 1
Introduction
Aminoacylase-1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. ACY1 has been assigned to chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes. [provided by RefSeq]
Entrez Gene ID
95
Alternative Names
ACY1D; ACYLASE
Function
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Biological Process
Aflatoxin metabolic process
Cellular amino acid metabolic process
Cellular Location
Cytoplasm
Involvement in disease
Aminoacylase-1 deficiency (ACY1D): An enzymatic deficiency resulting in encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids.

Chen, Z., Gao, J., Sun, J., Wu, Z., & Wang, B. (2021). Aminoacylase 1 (ACY-1) Mediates the Proliferation and Migration of Neuroblastoma Cells in Humans Through the ERK/Transforming Growth Factor β (TGF-β) Signaling Pathways. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 27, e928813-1.

Al-Helaly, L. A., & Mahmood, E. S. (2021). Biochemical and Histological Study of Aminoacylase-1 Purified from Amniotic Fluid in Rats with Oxidative Stress Induced by Lead Acetate. Baghdad Science Journal, 18(3), 0583-0583.

Xu, Z., Hu, Y., & Yu, Z. (2021). Effect of the ACY‑1 gene on HER2 and TRAIL expression in rectal carcinoma. Experimental and Therapeutic Medicine, 22(2), 1-7.

Wang, G., Li, H., & Hou, Y. (2021). LncRNA MAGI2-AS3 inhibits tumor progression and angiogenesis by regulating ACY1 via interacting with transcription factor HEY1 in clear cell renal cell carcinoma. Cancer Gene Therapy, 1-12.

Balamurugan, T. S. T., Huang, C. H., Chang, P. C., & Huang, S. T. (2018). Electrochemical molecular switch for the selective profiling of cysteine in live cells and whole blood and for the quantification of aminoacylase-1. Analytical chemistry, 90(21), 12631-12638.

Cheng, Q., Gu, S., Liu, Z., Wang, C. Z., & Li, X. (2017). Expressional divergence of the fatty acid-amino acid conjugate-hydrolyzing aminoacylase 1 (L-ACY-1) in Helicoverpa armigera and Helicoverpa assulta. Scientific reports, 7(1), 1-11.

Yu, B., Liu, X., Cao, X., Zhang, M., & Chang, H. (2017). Study of the expression and function of ACY1 in patients with colorectal cancer. Oncology letters, 13(4), 2459-2464.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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