Human Recombinant AXIN2 protein, GST Tag (V2LY-0526-LY2221)

Name: Human Recombinant AXIN2 protein, GST Tag
SKU: V2LY-0526-LY2221
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant AXIN2 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 130 kDa.

Molecule Mass

130 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

axin 2

Function

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Biological Process

Beta-catenin-TCF complex assembly Source: Reactome
Bone mineralization Source: Ensembl
Cell population proliferation Source: Ensembl
Cellular protein localization Source: BHF-UCL
Chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
Intramembranous ossification Source: Ensembl
Maintenance of DNA repeat elements Source: BHF-UCL
mRNA stabilization Source: BHF-UCL
Negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of osteoblast differentiation Source: Ensembl
Odontogenesis Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: Reactome
Positive regulation of cell death Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Regulation of centromeric sister chromatid cohesion Source: BHF-UCL
Regulation of chondrocyte development Source: Ensembl
Regulation of mismatch repair Source: BHF-UCL
Secondary heart field specification Source: Ensembl
Somitogenesis Source: Ensembl
Wnt signaling pathway Source: UniProtKB-KW

Cellular Location

Cytoplasm

Involvement in disease

Colorectal cancer (CRC): A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Oligodontia-colorectal cancer syndrome (ODCRCS): Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

PTM

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.

Niu, Z., Wang, F., Lv, S., Lv, Y., Liu, M., Fu, L., ... & Yuan, F. (2021). HNRNPU-AS1 regulates cell proliferation and apoptosis via miR-205-5p/AXIN2 axis and Wnt/β-catenin signaling pathway in cervical cancer. Molecular and Cellular Biology, MCB-00115.

Li, X., Li, Y., Liu, G., & Wu, W. (2021). New insights of the correlation between AXIN2 polymorphism and cancer risk and susceptibility: evidence from 72 studies. BMC cancer, 21(1), 1-15.

Kaur, G., Verma, R., Mukhopadhyay, C. S., & Sethi, R. (2021). Elevated pulmonary levels of Axin2 in mice exposed to herbicide 2, 4‐D with or without endotoxin. Journal of Biochemical and Molecular Toxicology, e22912.

Moshkovsky, A. R., & Kirschner, M. W. (2021). The non-redundant nature of the Axin2 regulatory network in the canonical Wnt signaling pathway. bioRxiv.

Cavallo, J. C., Scholpp, S., & Flegg, M. B. (2020). Delay-driven oscillations via Axin2 feedback in the Wnt/β-catenin signalling pathway. Journal of Theoretical Biology, 507, 110458.

Bernkopf, D. B., Brückner, M., Hadjihannas, M. V., & Behrens, J. (2019). An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy. Nature communications, 10(1), 1-14.

Chen, M., Liu, Y. Y., Zheng, M. Q., Wang, X. L., Gao, X. H., Chen, L., & Zhang, G. M. (2018). microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression. Oncology letters, 15(5), 7076-7082.

Haddaji Mastouri, M., De Coster, P., Zaghabani, A., Jammali, F., Raouahi, N., Ben Salem, A., ... & H'mida Ben Brahim, D. (2018). Genetic study of non‐syndromic tooth agenesis through the screening of paired box 9, msh homeobox 1, axin 2, and Wnt family member 10A genes: a case‐series. European journal of oral sciences, 126(1), 24-32.

Hloušková, A., Bielik, P., Bonczek, O., Balcar, V. J., & Šerý, O. (2017). Mutations in AXIN2 gene as a risk factor for tooth agenesis and cancer: A review. Neuroendocrinology Letters, 38(3).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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