AXIN2

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq]

axin 2

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.

Beta-catenin-TCF complex assembly Source: Reactome
Bone mineralization Source: Ensembl
Cell population proliferation Source: Ensembl
Cellular protein localization Source: BHF-UCL
Chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
Intramembranous ossification Source: Ensembl
Maintenance of DNA repeat elements Source: BHF-UCL
mRNA stabilization Source: BHF-UCL
Negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of osteoblast differentiation Source: Ensembl
Odontogenesis Source: BHF-UCL
Positive regulation of canonical Wnt signaling pathway Source: Reactome
Positive regulation of cell death Source: BHF-UCL
Positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Regulation of centromeric sister chromatid cohesion Source: BHF-UCL
Regulation of chondrocyte development Source: Ensembl
Regulation of mismatch repair Source: BHF-UCL
Secondary heart field specification Source: Ensembl
Somitogenesis Source: Ensembl
Wnt signaling pathway Source: UniProtKB-KW

Cytoplasm

Colorectal cancer (CRC): A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Oligodontia-colorectal cancer syndrome (ODCRCS): Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.