Human Recombinant CALCA protein, Fc Tag (V2LY-0526-LY6331)

Name: Human Recombinant CALCA protein, Fc Tag
SKU: V2LY-0526-LY6331
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

Fc Tag

Protein Construction

This product is Human Recombinant CALCA protein, Fc Tag consist of Amino Acid: 1-141 and predicts a molecular mass of 39.2 kDa.

Molecule Mass

39.2 kDa

Sequence

Amino Acid: 1-141

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Calcitonin Related Polypeptide Alpha

Function

Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.

Biological Process

Activation of adenylate cyclase activity Source: Ensembl
Activation of protein kinase activity Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Aging Source: Ensembl
Amyloid fibril formation Source: Reactome
Artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
Embryo implantation Source: UniProtKB
Feeding behavior Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: Ensembl
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of bone resorption Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of ossification Source: Ensembl
Negative regulation of smooth muscle contraction Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neuropeptide signaling pathway Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of heart contraction Source: Ensembl
Response to heat Source: Ensembl
Response to pain Source: Ensembl

Cellular Location

Secreted

Appelt, J., Baranowsky, A., Jahn, D., Yorgan, T., Köhli, P., Otto, E., ... & Keller, J. (2020). The neuropeptide calcitonin gene-related peptide alpha is essential for bone healing. EBioMedicine, 59, 102970.

Sherry Wu, J., Vyas, P., Glowatzki, E., & Fuchs, P. A. (2018). Opposing expression gradients of calcitonin‐related polypeptide alpha (Calca/Cgrpα) and tyrosine hydroxylase (Th) in type II afferent neurons of the mouse cochlea. Journal of Comparative Neurology, 526(6), 1073-1073.

Wu, J. S., Vyas, P., Glowatzki, E., & Fuchs, P. A. (2018). Opposing expression gradients of calcitonin‐related polypeptide alpha (Calca/Cgrpα) and tyrosine hydroxylase (Th) in type II afferent neurons of the mouse cochlea. Journal of Comparative Neurology, 526(3), 425-438.

Alkanli, N., Sipahi, T., Ay, A., Guldiken, B., Bakir, A., Alkanli, S. S., ... & Atilgan, E. (2017). Calcitonin related polypeptide alpha gene polymorphisms according to plasma total homocysteine levels in ischemic stroke patients of Trakya Region. Biotechnology & Biotechnological Equipment, 31(6), 1184-1191.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CALCA protein, His Tag (CAT#: V2LY-0526-LY6329)

Human Recombinant CALCA protein, His Tag-1 (CAT#: V2LY-0526-LY6330)

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Human Recombinant CALCA protein, His Tag-1 (CAT#: V2LY-0526-LY6330)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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