CALCA

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Full Name
Calcitonin Related Polypeptide Alpha
Function
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.
Biological Process
Activation of adenylate cyclase activity Source: Ensembl
Activation of protein kinase activity Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Aging Source: Ensembl
Amyloid fibril formation Source: Reactome
Artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
Embryo implantation Source: UniProtKB
Feeding behavior Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: Ensembl
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of bone resorption Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of ossification Source: Ensembl
Negative regulation of smooth muscle contraction Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neuropeptide signaling pathway Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of heart contraction Source: Ensembl
Response to heat Source: Ensembl
Response to pain Source: Ensembl
Cellular Location
Secreted
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Anti-CALCA antibodies

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Mouse Anti-CALCA Recombinant Antibody (CBYC-A923) (CBMAB-A4267-YC)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A923
Application*: WB, IP
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (13f2) (CBMAB-1283-CN)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13f2
Application*: WB, IP
Datasheet SDS

Human Recombinant CALCA protein, Fc Tag (V2LY-0526-LY6331)

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Target: CALCA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: Fc Tag
Datasheet SDS

Human Recombinant CALCA protein, His Tag-1 (V2LY-0526-LY6330)

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Target: CALCA
Expressed Host: E. coli
Sequence: Amino Acid: 26-141
Tag: His Tag
Datasheet SDS

Human Recombinant CALCA protein, His Tag (V2LY-0526-LY6329)

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Target: CALCA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: His Tag
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (CBT3574) (V2LY-0625-LY1355)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3574
Application*: WB
Datasheet SDS

Rabbit Anti-CALCA Recombinant Antibody (D5R8F) (CBMAB-C0011-CN)

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Target: CALCA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D5R8F
Application*: WB, IF
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0731) (CBMAB-C0786-FY)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0731
Application*: P
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0475) (CBMAB-C0522-FY)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0475
Application*: E
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0327) (CBMAB-C0363-FY)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0327
Application*: IH, WB
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0289) (CBMAB-C0320-FY)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0289
Application*: WB, IP
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (4B10) (CBMAB-C6625-LY)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B10
Application*: E, WB
Datasheet SDS

Mouse Anti-CALCA Recombinant Antibody (02) (CBMAB-C1650-LY)

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Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 02
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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