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CALCA

This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Full Name
Calcitonin Related Polypeptide Alpha
Function
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.
Biological Process
Activation of adenylate cyclase activity Source: Ensembl
Activation of protein kinase activity Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Aging Source: Ensembl
Amyloid fibril formation Source: Reactome
Artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
Embryo implantation Source: UniProtKB
Feeding behavior Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: Ensembl
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of bone resorption Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of ossification Source: Ensembl
Negative regulation of smooth muscle contraction Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neuropeptide signaling pathway Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of heart contraction Source: Ensembl
Response to heat Source: Ensembl
Response to pain Source: Ensembl
Cellular Location
Secreted

Anti-CALCA antibodies

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Mouse Anti-CALCA Recombinant Antibody (CAP289) (CBMAB-AP745LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP289
Application*: ICC, IHC, IP, WB

Mouse Anti-CALCA Recombinant Antibody (D4) (CBMAB-AP744LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: D4
Application*: ICC, IHC, IP, WB

Mouse Anti-CALCA Recombinant Antibody (CAP288) (CBMAB-AP743LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP288
Application*: ELISA, IHC

Mouse Anti-CALCA Recombinant Antibody (4901) (CBMAB-1285-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat, Mouse, Guinea pig, Human
Clone: 4901
Application*: F, IF, C, N

Mouse Anti-CALCA Recombinant Antibody (C1) (CBMAB-1284-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: C1
Application*: WB, IH, IC, IP

Mouse Anti-CALCA Recombinant Antibody (13f2) (CBMAB-1283-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13f2
Application*: IA, E, WB

Mouse Anti-CALCA Recombinant Antibody (13B9) (CBMAB-1282-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13B9
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (CBXC-2994) (CBMAB-C3851-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2994
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (CBXC-2367) (CBMAB-C3848-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBXC-2367
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (CBXC-2075) (CBMAB-C3845-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2075
Application*: WB, IH

Mouse Anti-CALCA Recombinant Antibody (CBXC-2370) (CBMAB-C3844-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2370
Application*: WB

Mouse Anti-CALCA Recombinant Antibody (Cn11 (BGN/1199/11)) (CBMAB-C0593-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: Cn11 (BGN/1199/11)
Application*: E

Mouse Anti-CALCA Recombinant Antibody (Cn 44 (BGN/1199/44)) (CBMAB-C0592-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Cn 44 (BGN/1199/44)
Application*: E

Mouse Anti-CALCA Recombinant Antibody (CBXC-2576) (CBMAB-C0245-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBXC-2576
Application*: WB, E, P, C

Mouse Anti-CALCA Recombinant Antibody (CBXC-2444) (CBMAB-C0044-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-2444
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (CBXC-2417) (CBMAB-C0029-CQ)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2417
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0735) (CBMAB-C0790-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0735
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0734) (CBMAB-C0789-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0734
Application*: ED, WB, E

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0733) (CBMAB-C0788-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBFYC-0733
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0732) (CBMAB-C0787-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0732
Application*: E, IH

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0731) (CBMAB-C0786-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0731
Application*: E, IH, WB

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0475) (CBMAB-C0522-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0475
Application*: WB, E, SE

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0327) (CBMAB-C0363-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0327
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (CBFYC-0289) (CBMAB-C0320-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0289
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (CF330) (CBMAB-FT008LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF330
Application*: ELISA, Immunofluorescence chromatography

Mouse Anti-CALCA Monoclonal Antibody (CBFYR0524) (CBMAB-R0524-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0524
Application*: SE

Mouse Anti-CALCA Monoclonal Antibody (CBFYR0523) (CBMAB-R0523-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYR0523
Application*: SE

Mouse Anti-CALCA Monoclonal Antibody (CBFYR0522) (CBMAB-R0522-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYR0522
Application*: SE

Mouse Anti-CALCA Monoclonal Antibody (CBFYR0521) (CBMAB-R0521-FY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYR0521
Application*: SE

Mouse Anti-CALCA Recombinant Antibody (CB179A) (CBMAB-CA179LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB179A
Application*: ELISA, IHC

Mouse Anti-CALCA Recombinant Antibody (CBMAB-AO310LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Application*: ELISA, ICC

Mouse Anti-CALCA Recombinant Antibody (15B520) (CBMAB-C3260-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 15B520
Application*: E

Mouse Anti-CALCA Recombinant Antibody (4) (CBMAB-AO144LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 4
Application*: ELISA, IHC

Mouse Anti-CALCA Recombinant Antibody (M904292) (CBMAB-C9637-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M904292
Application*: E, EP, WB

Mouse Anti-CALCA Recombinant Antibody (4G1H7) (CBMAB-R4268-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4G1H7
Application*: E, IH

Mouse Anti-CALCA Recombinant Antibody (5E544) (CBMAB-C1248-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E544
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (5E543) (CBMAB-C1247-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5E543
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (10B420) (CBMAB-C1241-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B420
Application*: E

Rabbit Anti-CALCA Recombinant Antibody (SP17) (CBMAB-C0011-CN)

Datasheet SDS
Target: CALCA
Host: Rabbit
Specificity: Human, Mouse, Rat
Clone: SP17
Application*: P

Mouse Anti-CALCA Recombinant Antibody (CBYY-C1949) (CBMAB-C3387-YY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C1949
Application*: E, P

Mouse Anti-CALCA Recombinant Antibody (3F6) (CBMAB-C6057-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F6
Application*: WB

Mouse Anti-CALCA Recombinant Antibody (CBYC-P033) (CBMAB-P0130-YC)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: CBYC-P033
Application*: WB, IC, P, C, E

Mouse Anti-CALCA Recombinant Antibody (C2) (CBMAB-P0129-YC)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C2
Application*: WB, IC, P, C, E, IP, IF, F

Mouse Anti-CALCA Recombinant Antibody (44d9) (CBMAB-P0128-YC)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat
Clone: 44d9
Application*: WB, E, IH, IC, IF

Mouse Anti-CALCA Recombinant Antibody (11D9.F3.C12.B8) (CBMAB-P0124-YC)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 11D9.F3.C12.B8
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (1) (CBMAB-P0123-YC)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1
Application*: E, WB, P

Mouse Anti-CALCA Recombinant Antibody (CBYC-A923) (CBMAB-A4267-YC)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: CBYC-A923
Application*: E, IH

Mouse Anti-CALCA Recombinant Antibody (13G11) (CBMAB-C0318-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13G11
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (24B2) (CBMAB-C0728-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 24B2
Application*: WB, SE

Mouse Anti-CALCA Recombinant Antibody (406CT21.4.3) (CBMAB-C1263-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 406CT21.4.3
Application*: P, WB

Mouse Anti-CALCA Recombinant Antibody (02) (CBMAB-C1650-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 02
Application*: E

Mouse Anti-CALCA Recombinant Antibody (11C94) (CBMAB-C2493-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11C94
Application*: E, C, WB

Mouse Anti-CALCA Recombinant Antibody (11G4) (CBMAB-C2524-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11G4
Application*: WB

Mouse Anti-CALCA Recombinant Antibody (5) (CBMAB-C2525-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: 5
Application*: WB, E, IH, P, C

Mouse Anti-CALCA Recombinant Antibody (13A93) (CBMAB-C2758-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 13A93
Application*: E, IH

Mouse Anti-CALCA Recombinant Antibody (14C12) (CBMAB-C2997-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14C12
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (15F6.F6.F9) (CBMAB-C3270-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 15F6.F6.F9
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (27A3) (CBMAB-C4518-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 27A3
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (2A12) (CBMAB-C4584-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2A12
Application*: WB

Mouse Anti-CALCA Recombinant Antibody (2D10) (CBMAB-C4843-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D10
Application*: P, WB

Mouse Anti-CALCA Recombinant Antibody (2F5) (CBMAB-C5103-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F5
Application*: WB

Mouse Anti-CALCA Recombinant Antibody (10B419) (CBMAB-C1240-CN)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10B419
Application*: E

Mouse Anti-CALCA Recombinant Antibody (2H3) (CBMAB-C5257-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2H3
Application*: WB

Mouse Anti-CALCA Recombinant Antibody (2Q2268) (CBMAB-C5349-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG
Specificity: Guinea pig, Human
Clone: 2Q2268
Application*: E, C, WB

Mouse Anti-CALCA Recombinant Antibody (38F11) (CBMAB-C5601-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 38F11
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (4B10) (CBMAB-C6625-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B10
Application*: E, WB

Mouse Anti-CALCA Recombinant Antibody (4C8.H6.D4) (CBMAB-C6752-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 4C8.H6.D4
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (8B5.A3.D5.D3.G6.E7) (CBMAB-C9057-LY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: 8B5.A3.D5.D3.G6.E7
Application*: WB, E

Mouse Anti-CALCA Recombinant Antibody (CBYY-C0883) (CBMAB-C2320-YY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0883
Application*: WB

Mouse Anti-CALCA Recombinant Antibody (CBYY-C0886) (CBMAB-C2323-YY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C0886
Application*: E, IH

Mouse Anti-CALCA Recombinant Antibody (CBYY-C0885) (CBMAB-C2322-YY)

Datasheet SDS
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1, λ
Specificity: Human
Clone: CBYY-C0885
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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