CALCA
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]
Full Name
Calcitonin Related Polypeptide Alpha
Function
Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones.
Katacalcin is a potent plasma calcium-lowering peptide.
Katacalcin is a potent plasma calcium-lowering peptide.
Biological Process
Activation of adenylate cyclase activity Source: Ensembl
Activation of protein kinase activity Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Aging Source: Ensembl
Amyloid fibril formation Source: Reactome
Artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
Embryo implantation Source: UniProtKB
Feeding behavior Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: Ensembl
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of bone resorption Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of ossification Source: Ensembl
Negative regulation of smooth muscle contraction Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neuropeptide signaling pathway Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of heart contraction Source: Ensembl
Response to heat Source: Ensembl
Response to pain Source: Ensembl
Activation of protein kinase activity Source: UniProtKB
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Aging Source: Ensembl
Amyloid fibril formation Source: Reactome
Artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
Cellular response to nerve growth factor stimulus Source: Ensembl
Cellular response to tumor necrosis factor Source: Ensembl
Detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
Embryo implantation Source: UniProtKB
Feeding behavior Source: Ensembl
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: Ensembl
Monocyte chemotaxis Source: BHF-UCL
Negative regulation of bone resorption Source: UniProtKB
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Negative regulation of ossification Source: Ensembl
Negative regulation of smooth muscle contraction Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Neuropeptide signaling pathway Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling Pathway Source: UniProtKB
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of heart contraction Source: Ensembl
Response to heat Source: Ensembl
Response to pain Source: Ensembl
Cellular Location
Secreted
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Anti-CALCA antibodies
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CompareTarget: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A923
Application*: WB, IP
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13f2
Application*: WB, IP
Target: CALCA
Sensitivity: 0.0025 ng/mL
Detection Range: 0.005-2 ng/mL
Sample Type: Serum, Plasma, Urine, Ascites, Cerebrospinal fluid, Tissue
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CALCA
Sensitivity: 0.0093 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Target: CALCA
Sensitivity: 0.0049 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Target: CALCA
Sensitivity: 0.0048 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Dog
Assay Type: Sandwich
Reactivity: Dog
Target: Calca
Sensitivity: 0.00021 ng/mL
Detection Range: 0.0005-0.2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: CALCA
Sensitivity: 0.0014 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Cattle
Assay Type: Sandwich
Reactivity: Cattle
Target: CALCA
Sensitivity: 0.0023 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Dog
Assay Type: Sandwich
Reactivity: Dog
Target: Calca
Sensitivity: 0.0033 ng/mL
Detection Range: 0.007-1.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: CALCA
Sensitivity: 0.25 mmol/L
Detection Range: 0.5-200 mmol/L
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: CALCA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: Fc Tag
Target: CALCA
Expressed Host: E. coli
Sequence: Amino Acid: 26-141
Tag: His Tag
Target: CALCA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-141
Tag: His Tag
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3574
Application*: WB
Target: CALCA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D5R8F
Application*: WB, IF
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-0731
Application*: P
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0475
Application*: E
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0327
Application*: IH, WB
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0289
Application*: WB, IP
Target: CALCA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B10
Application*: E, WB
Target: CALCA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 02
Application*: E
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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