Human Recombinant CCL13 protein, His Tag (V2LY-0526-LY5482)

Name: Human Recombinant CCL13 protein, His Tag
SKU: V2LY-0526-LY5482
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Yeast

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CCL13 protein, His Tag consist of Amino Acid: 24-98 and predicts a molecular mass of 10 kDa.

Molecule Mass

10 kDa

Sequence

Amino Acid: 24-98

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Ligand 13

Function

Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Regulation of cell shape Source: UniProtKB
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.

Hussain, M., Liu, J., Wang, G. Z., & Zhou, G. B. (2021). CXCL13 Signaling in the Tumor Microenvironment. In Tumor Microenvironment (pp. 71-90). Springer, Cham.

Wu, N., Xue, C., Fan, Y., Ma, R., Cai, D., & Ye, Q. (2021). CC-Chemokine Ligand 18, CXC Motif Chemokine 13, and Osteopontin as Biomarkers of Silicosis and Asbestosis: A Case-Control Study.

Heinrichs, M., Ashour, D., Siegel, J., Büchner, L., Wedekind, G., Heinze, K. G., ... & Ramos, G. C. (2021). The healing myocardium mobilises a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism. Cardiovascular Research.

Tsai, C. H., Chen, C. J., Gong, C. L., Liu, S. C., Chen, P. C., Huang, C. C., ... & Tang, C. H. (2021). CXCL13/CXCR5 axis facilitates endothelial progenitor cell homing and angiogenesis during rheumatoid arthritis progression. Cell death & disease, 12(9), 1-11.

Chen, F., Li, X., Li, Z., Zhou, Y., Qiang, Z., & Ma, H. (2020). The roles of chemokine (CXC motif) ligand 13 in spinal cord ischemia-reperfusion injury in rats. Brain research, 1727, 146489.

Liu, J. F., Lee, C. W., Lin, C. Y., Chao, C. C., Chang, T. M., Han, C. K., ... & Tang, C. H. (2020). CXCL13/CXCR5 interaction facilitates VCAM-1-dependent migration in human osteosarcoma. International journal of molecular sciences, 21(17), 6095.

Zhu, L., Zhang, G., Wang, P., Zhang, L., Ji, J., Liu, X., ... & Wang, X. (2019). The effect of CXC motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy. Photodiagnosis and photodynamic therapy, 26, 389-394.

Hussain, M., Adah, D., Tariq, M., Lu, Y., Zhang, J., & Liu, J. (2019). CXCL13/CXCR5 signaling axis in cancer. Life sciences, 227, 175-186.

Kazanietz, M. G., Durando, M., & Cooke, M. (2019). CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond. Frontiers in endocrinology, 10, 471.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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