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Mouse Anti-CCL13 Recombinant Antibody (CBFYM-0901) (CBMAB-M1049-FY)

This product is mouse antibody that recognizes CCL13. The antibody CBFYM-0901 can be used for immunoassay techniques such as: FC, Neut.
See all CCL13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-0901
Antibody Isotype
IgG1
Application
FC, Neut

Basic Information

Immunogen
Recombinant MCP4
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 13
Introduction
CCL13 is a Protein Coding gene. Diseases associated with CCL13 include Allergic Hypersensitivity Disease and Asthma. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CCL2.
Entrez Gene ID
6357
UniProt ID
Q99616
Alternative Names
C-C Motif Chemokine Ligand 13; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 13; Monocyte Chemoattractant Protein 4; Chemokine (C-C Motif) Ligand 13; Monocyte Chemotactic Protein 4; Small-Inducible Cytokine A13; CK-Beta-10; SCYA13; MCP-4
Function
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Regulation of cell shape Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.

Hussain, M., Liu, J., Wang, G. Z., & Zhou, G. B. (2021). CXCL13 Signaling in the Tumor Microenvironment. In Tumor Microenvironment (pp. 71-90). Springer, Cham.

Wu, N., Xue, C., Fan, Y., Ma, R., Cai, D., & Ye, Q. (2021). CC-Chemokine Ligand 18, CXC Motif Chemokine 13, and Osteopontin as Biomarkers of Silicosis and Asbestosis: A Case-Control Study.

Heinrichs, M., Ashour, D., Siegel, J., Büchner, L., Wedekind, G., Heinze, K. G., ... & Ramos, G. C. (2021). The healing myocardium mobilises a distinct B-cell subset through a CXCL13-CXCR5-dependent mechanism. Cardiovascular Research.

Tsai, C. H., Chen, C. J., Gong, C. L., Liu, S. C., Chen, P. C., Huang, C. C., ... & Tang, C. H. (2021). CXCL13/CXCR5 axis facilitates endothelial progenitor cell homing and angiogenesis during rheumatoid arthritis progression. Cell death & disease, 12(9), 1-11.

Chen, F., Li, X., Li, Z., Zhou, Y., Qiang, Z., & Ma, H. (2020). The roles of chemokine (CXC motif) ligand 13 in spinal cord ischemia-reperfusion injury in rats. Brain research, 1727, 146489.

Liu, J. F., Lee, C. W., Lin, C. Y., Chao, C. C., Chang, T. M., Han, C. K., ... & Tang, C. H. (2020). CXCL13/CXCR5 interaction facilitates VCAM-1-dependent migration in human osteosarcoma. International journal of molecular sciences, 21(17), 6095.

Zhu, L., Zhang, G., Wang, P., Zhang, L., Ji, J., Liu, X., ... & Wang, X. (2019). The effect of CXC motif chemokine ligand 13 in cutaneous squamous cell carcinoma treated with aminolevulinic acid-photodynamic therapy. Photodiagnosis and photodynamic therapy, 26, 389-394.

Hussain, M., Adah, D., Tariq, M., Lu, Y., Zhang, J., & Liu, J. (2019). CXCL13/CXCR5 signaling axis in cancer. Life sciences, 227, 175-186.

Kazanietz, M. G., Durando, M., & Cooke, M. (2019). CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond. Frontiers in endocrinology, 10, 471.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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