Human Recombinant CCNC protein, GST Tag (V2LY-0526-LY3452)

Name: Human Recombinant CCNC protein, GST Tag
SKU: V2LY-0526-LY3452
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CCNC protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 55 kDa.

Molecule Mass

55 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Cyclin C

Function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Biological Process

Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription initiation from RNA polymerase II promoter Source: Reactome

Cellular Location

Nucleus

Tang, M., Pei, G., Su, D., Wang, C., Feng, X., Srivastava, M., ... & Chen, J. (2021). Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2. Nucleic acids research, 49(13), 7476-7491.

Lloyd, R. L., Urban, V., Muñoz-Martínez, F., Ayestaran, I., Thomas, J. C., de Renty, C., ... & Jackson, S. P. (2021). Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress. Nucleic acids research, 49(15), 8665-8683.

Ponce, J. M., Coen, G., Spitler, K. M., Dragisic, N., Martins, I., Hinton Jr, A., ... & Grueter, C. E. (2020). Stress‐Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. Journal of the American Heart Association, 9(7), e014366.

Stieg, D. C., Cooper, K. F., & Strich, R. (2020). The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription. Journal of Biological Chemistry, 295(48), 16280-16291.

Jezek, J., Wang, K., Yan, R., Di Cristofano, A., Cooper, K. F., & Strich, R. (2019). Synergistic repression of thyroid hyperplasia by cyclin C and Pten. Journal of cell science, 132(16), jcs230029.

Ježek, J., Smethurst, D. G., Stieg, D. C., Kiss, Z. A. C., Hanley, S. E., Ganesan, V., ... & Strich, R. (2019). Cyclin C: The story of a non-cycling cyclin. Biology, 8(1), 3.

Jezek, J., Chang, K. T., Joshi, A. M., & Strich, R. (2019). Mitochondrial translocation of cyclin C stimulates intrinsic apoptosis through Bax recruitment. EMBO reports, 20(9), e47425.

Stieg, D. C., Chang, K. T., Cooper, K. F., & Strich, R. (2019). Cyclin C regulated oxidative stress responsive transcriptome in Mus musculus embryonic fibroblasts. G3: Genes, Genomes, Genetics, 9(6), 1901-1908.

Ganesan, V., Willis, S. D., Chang, K. T., Beluch, S., Cooper, K. F., & Strich, R. (2019). Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission. Molecular biology of the cell, 30(3), 302-311.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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