CCNC

CCNC (Cyclin C) is a Protein Coding gene. Among its related pathways are Signaling by NOTCH1 and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNK.

Full Name

Cyclin C

Function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Biological Process

Positive regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Regulation of transcription initiation from RNA polymerase II promoter Source: Reactome

Cellular Location

Nucleus