Human Recombinant CCND2 protein, GST Tag (V2LY-0526-LY3456)

Name: Human Recombinant CCND2 protein, GST Tag
SKU: V2LY-0526-LY3456
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CCND2 protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 60 kDa.

Molecule Mass

60 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Cyclin D2

Function

Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Biological Process

Cell division Source: UniProtKB-KW
Mitotic cell cycle phase transition Source: GO_Central
Negative regulation of apoptotic process Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central

Cellular Location

Cytoplasm; Nucleus; Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Isoform 2: Cytoplasm

Involvement in disease

Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3): A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.

PTM

Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Qian, Y., Wang, H., Zhang, Y., Wang, J. W., Fan, Y. C., Gao, S., & Wang, K. (2021). Hypermethylation of Cyclin D2 Predicts Poor Prognosis of Hepatitis B Virus-Associated Hepatocellular Carcinoma after Hepatectomy. The Tohoku Journal of Experimental Medicine, 254(3), 233-243.

Zhu, S., Zhang, J., Cui, Y., Tang, X., Gao, X., Li, D., & Jia, W. (2020). Long non-coding RNA HOXA11-AS upregulates Cyclin D2 to inhibit apoptosis and promote cell cycle progression in nephroblastoma by recruiting forkhead box P2. American journal of cancer research, 10(1), 284.

Qian, Y., Wang, J. W., Yu-Fang, X. D. Y., Fan, Y. C., Gao, S., & Wang, K. (2020). Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e927444-1.

Pandya, P., Jethva, M., Rubin, E., Birnbaum, R. Y., Braiman, A., & Isakov, N. (2019). PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter. Cell death & disease, 10(10), 1-15.

Ding, Z. Y., Li, R., Zhang, Q. J., Wang, Y., Jiang, Y., Meng, Q. Y., ... & Wu, G. H. (2019). Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta‐analysis. Cancer medicine, 8(6), 2717-2729.

Huang, R., Hu, Z., Cao, Y., Li, H., Zhang, H., Su, W., ... & Jiang, L. (2019). MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression. EBioMedicine, 40, 685-694.

Cameron, S. R., Nandi, S., Kahn, T. G., Barrasa, J. I., Stenberg, P., & Schwartz, Y. B. (2018). PTE, a novel module to target Polycomb Repressive Complex 1 to the human cyclin D2 (CCND2) oncogene. Journal of Biological Chemistry, 293(37), 14342-14358.

Koochakpoor, G., Mirmiran, P., Daneshpour, M. S., Hosseini-Esfahani, F., Sedaghati-Khayat, B., Hosseini, S. A., & Azizi, F. (2018). Dietary factors influence the association of cyclin D2 polymorphism rs11063069 with the risk of metabolic syndrome. Nutrition Research, 52, 48-56.

Zhao, Z., Yang, F., Liu, Y., Fu, K., & Jing, S. (2018). MicroRNA‑409‑3p suppresses cell proliferation and cell cycle progression by targeting cyclin D2 in papillary thyroid carcinoma. Oncology letters, 16(4), 5237-5242.

Wang, Y., Xue, J., Kuang, H., Zhou, X., Liao, L., & Yin, F. (2017). microRNA-1297 inhibits the growth and metastasis of colorectal cancer by suppressing cyclin D2 expression. DNA and cell biology, 36(11), 991-999.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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Isotype control

For research use only. Not intended for any clinical use.

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