Human Recombinant CCNK protein, GST Tag (V2LY-0526-LY2635)

Name: Human Recombinant CCNK protein, GST Tag
SKU: V2LY-0526-LY2635
Rating: 5 (1 reviews)

See all CCNK antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CCNK protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 67 kDa.

Molecule Mass

67 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS, Tween80

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

cyclin K

Function

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: MGI
Negative regulation by host of viral genome replication Source: CACAO
Positive regulation of DNA-templated transcription, elongation Source: GO_Central
Positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues Source: CACAO
Positive regulation of transcription by RNA polymerase II Source: Reactome
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
snRNA transcription by RNA polymerase II Source: Reactome
Transcription by RNA polymerase II Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome

Cellular Location

Nucleus

Involvement in disease

Intellectual developmental disorder with hypertelorism and distinctive facies (IDDHDF): An autosomal dominant neurodevelopmental disorder characterized by developmental delay and intellectual disability, language defects, and distinctive facial dysmorphism including high hairline, hypertelorism, thin eyebrows, dysmorphic ears, broad nasal bridge and tip, and narrow jaw.

Dieter, S. M., Siegl, C., Codó, P. L., Huerta, M., Ostermann-Parucha, A. L., Schulz, E., ... & Glimm, H. (2021). Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell reports, 36(3), 109394.

Niu, T., Li, K., Jiang, L., Zhou, Z., Hong, J., Chen, X., ... & Zhu, C. L. (2021). Noncovalent CDK12/13 dual inhibitors-based PROTACs degrade CDK12-Cyclin K complex and induce synthetic lethality with PARP inhibitor. European Journal of Medicinal Chemistry, 114012.

Lv, L., Chen, P., Cao, L., Li, Y., Zeng, Z., Cui, Y., ... & Han, T. (2020). Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife, 9, e59994.

Słabicki, M., Kozicka, Z., Petzold, G., Li, Y. D., Manojkumar, M., Bunker, R. D., ... & Ebert, B. L. (2020). The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature, 585(7824), 293-297.

Żuryń, A., Krajewski, A., Klimaszewska‑Wiśniewska, A., Grzanka, A., & Grzanka, D. (2019). Expression of cyclin B1, D1 and K in non‑small cell lung cancer H1299 cells following treatment with sulforaphane. Oncology reports, 41(2), 1313-1323.

Hoshii, T., Cifani, P., Feng, Z., Huang, C. H., Koche, R., Chen, C. W., ... & Armstrong, S. A. (2018). A non-catalytic function of SETD1A regulates cyclin K and the DNA damage response. Cell, 172(5), 1007-1021.

Fan, Y., Yin, W., Hu, B., Kline, A. D., Zhang, V. W., Liang, D., ... & Yu, Y. (2018). De novo mutations of CCNK cause a syndromic neurodevelopmental disorder with distinctive facial dysmorphism. The American Journal of Human Genetics, 103(3), 448-455.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant CCNK protein, GST Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-CCNK Recombinant Antibody (3B7-1B9) (CAT#: CBMAB-C5749-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry