CCNK

The protein encoded by this gene is a member of the transcription cyclin family. These cyclins may regulate transcription through their association with and activation of cyclin-dependent kinases (CDK) that phosphorylate the C-terminal domain (CTD) of the large subunit of RNA polymerase II. This gene product may play a dual role in regulating CDK and RNA polymerase II activities. [provided by RefSeq]

Full Name

cyclin K

Function

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Cellular response to DNA damage stimulus Source: MGI
Negative regulation by host of viral genome replication Source: CACAO
Positive regulation of DNA-templated transcription, elongation Source: GO_Central
Positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues Source: CACAO
Positive regulation of transcription by RNA polymerase II Source: Reactome
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
snRNA transcription by RNA polymerase II Source: Reactome
Transcription by RNA polymerase II Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome

Cellular Location

Nucleus

Involvement in disease

Intellectual developmental disorder with hypertelorism and distinctive facies (IDDHDF): An autosomal dominant neurodevelopmental disorder characterized by developmental delay and intellectual disability, language defects, and distinctive facial dysmorphism including high hairline, hypertelorism, thin eyebrows, dysmorphic ears, broad nasal bridge and tip, and narrow jaw.