Human Recombinant CCNO protein, GST Tag (V2LY-0526-LY2636)

Name: Human Recombinant CCNO protein, GST Tag
SKU: V2LY-0526-LY2636
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CCNO protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 69 kDa.

Molecule Mass

69 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Cyclin O

Function

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.

Biological Process

Cell division Source: UniProtKB-KW
Cilium assembly Source: UniProtKB
Mitotic cell cycle Source: UniProtKB
Mitotic cell cycle phase transition Source: GO_Central
Multi-ciliated epithelial cell differentiation Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Response to drug Source: Ensembl

Cellular Location

Cytoplasm; Nucleolus. Localizes to the apical part of cytoplasm.

Involvement in disease

Ciliary dyskinesia, primary, 29 (CILD29): The disease is caused by variants affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639). A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition.

Xu, X., Dong, L., Ma, C., Xu, X., Wu, H., Wang, J., ... & Wei, Z. (2021). Establishment of an induced pluripotent stem cell line from a patient with primary ciliary dyskinesia carrying biallelic mutations in CCNO. Stem Cell Research, 53, 102372.

Ma, C., Wu, H., Zhu, D., Wang, Y., Shen, Q., Cheng, H., ... & Xu, X. (2021). Bi‐allelic mutations in MCIDA S and CCNO cause human infertility associated with abnormal gamete transport. Clinical Genetics, 100(6), 731-742.

Wang, J., & Chen, S. (2020). RACK1 promotes miR-302b/c/d-3p expression and inhibits CCNO expression to induce cell apoptosis in cervical squamous cell carcinoma. Cancer Cell International, 20(1), 1-12.

Dahlmann, J., Sahabian, A., Drick, N., Haase, A., Göhring, G., Lachmann, N., ... & Olmer, R. (2020). Generation of two hiPSC lines (MHHi016-A, MHHi016-B) from a primary ciliary dyskinesia patient carrying a homozygous 5 bp duplication (c. 248_252dup (p. Gly85Cysfs* 11)) in exon 1 of the CCNO gene. Stem Cell Research, 46, 101850.

Li, L., Cao, Y., Zhou, H., Li, Y., He, B., Zhou, X., ... & Ye, L. (2018). Knockdown of CCNO decreases the tumorigenicity of gastric cancer by inducing apoptosis. OncoTargets and therapy, 11, 7471.

Núnez-Ollé, M., Jung, C., Terré, B., Balsiger, N. A., Plata, C., Roset, R., ... & Gil-Gómez, G. (2017). Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility. Oncotarget, 8(59), 99261.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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