Human Recombinant CCR9-VLP protein, Flag & His-Strep Tag (V2LY-0526-LY2650)

Name: Human Recombinant CCR9-VLP protein, Flag & His-Strep Tag
SKU: V2LY-0526-LY2650
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

Flag & His-Strep Tag

Protein Construction

This product is Human Recombinant CCR9-VLP protein, Flag & His-Strep Tag consist of Amino Acid: 1-369 and predicts a molecular mass of 45.9 kDa.

Molecule Mass

45.9 kDa

Sequence

Amino Acid: 1-369

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

NaAC, NaCl, Glycerol, CaCl2

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -70°C or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-C Motif Chemokine Receptor 9

Function

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Biological Process

Calcium-mediated signaling Source: GO_Central
CD8-positive, gamma-delta intraepithelial T cell differentiation Source: Ensembl
Cell chemotaxis Source: GO_Central
Cellular defense response Source: ProtInc
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 1-48
Helical: 49-74
Cytoplasmic: 75-85
Helical: 86-109
Extracellular: 110-120
Helical: 121-150
Cytoplasmic: 151-159
Helical: 160-185
Extracellular: 186-208
Helical: 209-243
Cytoplasmic: 244-248
Helical: 249-283
Extracellular: 284-290
Helical: 291-321
Cytoplasmic: 322-369

Amiya, T., Nakamoto, N., Irie, J., Taniki, N., Chu, P. S., Koda, Y., ... & Kanai, T. (2021). CC motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice. Diabetologia, 64(3), 603-617.

Morikawa, R., Nakamoto, N., Amiya, T., Chu, P. S., Koda, Y., Teratani, T., ... & Kanai, T. (2021). Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis. Journal of Hepatology, 74(3), 511-521.

Nanamiya, R., Takei, J., Asano, T., Tanaka, T., Sano, M., Nakamura, T., ... & Kato, Y. (2021). Development of Anti-Human CC Chemokine Receptor 9 Monoclonal Antibodies for Flow Cytometry. Monoclonal antibodies in immunodiagnosis and immunotherapy, 40(3), 101-106.

Niu, Y., Tang, D., Fan, L., Gao, W., & Lin, H. (2020). CCL25 promotes the migration and invasion of non‑small cell lung cancer cells by regulating VEGF and MMPs in a CCR9‑dependent manner. Experimental and therapeutic medicine, 19(6), 3571-3580.

Atanes, P., Lee, V., Huang, G. C., & Persaud, S. J. (2020). The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes. Metabolism, 113, 154394.

Korbecki, J., Grochans, S., Gutowska, I., Barczak, K., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 ligands. International journal of molecular sciences, 21(20), 7619.

Igaki, K., Komoike, Y., Nakamura, Y., Watanabe, T., Yamasaki, M., Fleming, P., ... & Tsuchimori, N. (2018). MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model. International immunopharmacology, 60, 160-169.

Wang, C., Liu, Z., Xu, Z., Wu, X., Zhang, D., Zhang, Z., & Wei, J. (2018). The role of chemokine receptor 9/chemokine ligand 25 signaling: From immune cells to cancer cells. Oncology letters, 16(2), 2071-2077.

Hu, Y., Ma, A., Lin, S., Yang, Y., & Hong, G. (2017). Novel peptide screened from a phage display library antagonizes the activity of CC chemokine receptor 9. Oncology letters, 14(6), 6471-6476.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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