Human Recombinant CD38 protein, ECD, His Tag (V2LY-0526-LY2823)

Name: Human Recombinant CD38 protein, ECD, His Tag
SKU: V2LY-0526-LY2823
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CD38 protein, ECD, His Tag consist of Amino Acid: 43-300 and predicts a molecular mass of 31.3 kDa.

Molecule Mass

31.3 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 43-300

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE.≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

CD38 Molecule

Alternative Names

CD38 Molecule; ADP-Ribosyl Cyclase 1; 2-Phospho-Cyclic-ADP-Ribose Transferase; Cyclic ADP-Ribose Hydrolase 1; 2-Phospho-ADP-Ribosyl Cyclase; NAD(+) Nucleosidase; CD38 Antigen (P45); ADPRC 1; 2-Phospho-ADP-Ribosyl Cyclase/2-Phospho-Cyclic-ADP-Ribose Transferase; Ecto-Nicotinamide Adenine Dinucleotide Glycohydrolase;

Function

Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Biological Process

Apoptotic signaling pathway Source: ProtInc
Artery smooth muscle contraction Source: Ensembl
B cell receptor signaling pathway Source: UniProtKB
Female pregnancy Source: Ensembl
Long-term synaptic depression Source: Ensembl
NAD metabolic process Source: Reactome
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of bone resorption Source: Ensembl
Negative regulation of neuron projection development Source: Ensembl
Negative regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of B cell proliferation Source: UniProtKB
Positive regulation of cell growth Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Positive regulation of insulin secretion Source: Ensembl
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of vasoconstriction Source: Ensembl
Response to drug Source: UniProtKB
Response to estradiol Source: Ensembl
Response to hydroperoxide Source: Ensembl
Response to hypoxia Source: Ensembl
Response to interleukin-1 Source: Ensembl
Response to progesterone Source: Ensembl
Response to retinoic acid Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Membrane

Topology

Cytoplasmic: 1-21
Helical: 22-42
Extracellular: 43-300

García-Guerrero, E., Götz, R., Doose, S., Sauer, M., Rodríguez-Gil, A., Nerreter, T., ... & Danhof, S. (2021). Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab. Leukemia, 35(1), 201-214.

Piedra-Quintero, Z. L., Wilson, Z., Nava, P., & Guerau-de-Arellano, M. (2020). CD38: an immunomodulatory molecule in inflammation and autoimmunity. Frontiers in immunology, 11, 3111.

Katsuyama, E., Suarez-Fueyo, A., Bradley, S. J., Mizui, M., Marin, A. V., Mulki, L., ... & Tsokos, G. C. (2020). The CD38/NAD/SIRTUIN1/EZH2 axis mitigates cytotoxic CD8 T cell function and identifies patients with SLE prone to infections. Cell reports, 30(1), 112-123.

Higashida, H., Hashii, M., Tanaka, Y., Matsukawa, S., Higuchi, Y., Gabata, R., ... & Lopatina, O. (2020). CD38, CD157, and RAGE as molecular determinants for social behavior. Cells, 9(1), 62.

Glaría, E., & Valledor, A. F. (2020). Roles of CD38 in the Immune Response to Infection. Cells, 9(1), 228.

Ning, L., Shan, G., Sun, Z., Zhang, F., Xu, C., Lou, X., ... & Xu, G. (2019). Quantitative proteomic analysis reveals the deregulation of nicotinamide adenine dinucleotide metabolism and CD38 in inflammatory bowel disease. BioMed research international, 2019.

Morandi, F., Airoldi, I., Marimpietri, D., Bracci, C., Faini, A. C., & Gramignoli, R. (2019). CD38, a receptor with multifunctional activities: from modulatory functions on regulatory cell subsets and extracellular vesicles, to a target for therapeutic strategies. Cells, 8(12), 1527.

Malavasi, F., & Faini, A. C. (2019). Mechanism of action of a new anti-CD38 antibody: enhancing myeloma immunotherapy. Clinical Cancer Research, 25(10), 2946-2948.

van de Donk, N. W., Richardson, P. G., & Malavasi, F. (2018). CD38 antibodies in multiple myeloma: back to the future. Blood, The Journal of the American Society of Hematology, 131(1), 13-29.

Van De Donk, N. W., & Usmani, S. Z. (2018). CD38 antibodies in multiple myeloma: mechanisms of action and modes of resistance. Frontiers in immunology, 9, 2134.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CD38-VLP protein (CAT#: V2LY-0526-LY156)

Cynomolgus, Rhesus Recombinant CD38 protein, ECD, His Tag (CAT#: V2LY-0526-LY1688)

Cynomolgus, Rhesus Recombinant CD38 protein, hFc Tag (CAT#: V2LY-0526-LY1689)

Human Recombinant CD38 protein, ECD, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY2819)

Human Recombinant CD38 protein, ECD, AF647 Conjugated, His Tag-1 (CAT#: V2LY-0526-LY2820)

Human Recombinant CD38 protein, ECD, hFc Tag (CAT#: V2LY-0526-LY2821)

Human Recombinant CD38 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2822)

Human Recombinant CD38 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY2824)

Human Recombinant CD38 protein, Biotin Conjugated, hFc & AVI Tag (CAT#: V2LY-0526-LY2825)

Human Recombinant CD38 protein, ECD, PE Conjugated, His Tag (CAT#: V2LY-0526-LY2827)

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Cynomolgus, Rhesus Recombinant CD38 protein, hFc Tag (CAT#: V2LY-0526-LY1689)

Human Recombinant CD38 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2822)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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