Human Recombinant CRIPT protein, His Tag (V2LY-0526-LY3375)

Name: Human Recombinant CRIPT protein, His Tag
SKU: V2LY-0526-LY3375
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CRIPT protein, His Tag consist of Amino Acid: 1-101 and predicts a molecular mass of 13.1 kDa.

Molecule Mass

13.1 kDa

Sequence

Amino Acid: 1-101

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS, Glycerol, Trehalose, Tween80

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

cysteine-rich PDZ-binding protein

Function

Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses.

Biological Process

Cytoplasmic microtubule organization Source: UniProtKB
Establishment of protein localization Source: UniProtKB
Protein localization to microtubule Source: UniProtKB
Regulation of postsynaptic density protein 95 clustering Source: UniProtKB

Cellular Location

Cytoplasm; Synapse; Dendritic spine. Colocalizes with DLG4 in asymmetric synapses.

Involvement in disease

Short stature with microcephaly and distinctive facies (SSMCF):
An autosomal recessive disease characterized by dwarfism, microcephaly, and distinctive facial dysmorphism involving frontal bossing, high forehead, sparse hair and eyebrows, telecanthus, mild proptosis, anteverted nares, and flat nasal bridge.

Omelchenko, A., Menon, H., Donofrio, S. G., Kumar, G., Chapman, H. M., Roshal, J., ... & Firestein, B. L. (2020). Interaction between CRIPT and PSD-95 is required for proper dendritic arborization in hippocampal neurons. Molecular neurobiology, 57(5), 2479-2493.

Zhang, L., Jablonski, A. M., Mojsilovic-Petrovic, J., Ding, H., Seeholzer, S., Newton, I. P., ... & Kalb, R. G. (2017). SAP97 binding partner CRIPT promotes dendrite growth in vitro and in vivo. Eneuro, 4(6).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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