Human Recombinant CTSS protein, His Tag (V2LY-0526-LY2609)

Name: Human Recombinant CTSS protein, His Tag
SKU: V2LY-0526-LY2609
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant CTSS protein, His Tag consist of Amino Acid: 1-331 and predicts a molecular mass of 37 kDa.

Molecule Mass

37 kDa

Verified

HPLC

Sequence

Amino Acid: 1-331

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Cathepsin S

Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035).

The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L.

Biological Process

Adaptive immune response Source: UniProtKB
Antigen processing and presentation Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: UniProtKB
Antigen processing and presentation of peptide antigen Source: CACAO
Basement membrane disassembly Source: BHF-UCL
Cellular response to thyroid hormone stimulus Source: UniProtKB
Collagen catabolic process Source: BHF-UCL
Extracellular matrix disassembly Source: Reactome
Immune response Source: GO_Central
Neutrophil degranulation Source: Reactome
Positive regulation of cation channel activity Source: CACAO
Protein processing Source: CACAO
Proteolysis Source: CAFA
Proteolysis involved in cellular protein catabolic process Source: BHF-UCL
Response to acidic pH Source: CACAO
Toll-like receptor signaling pathway Source: Reactome

Cellular Location

Secreted; Lysosome; Phagosome

Yoo, Y., Choi, E., Kim, Y., Cha, Y., Um, E., Kim, Y., ... & Lee, Y. S. (2022). Therapeutic potential of targeting cathepsin S in pulmonary fibrosis. Biomedicine & Pharmacotherapy, 145, 112245.

Bararia, D., Hildebrand, J. A., Stolz, S., Haebe, S., Alig, S., Trevisani, C. P., ... & Weigert, O. (2020). Cathepsin S alterations induce a tumor-promoting immune microenvironment in follicular lymphoma. Cell reports, 31(5), 107522.

Brown, R., Nath, S., Lora, A., Samaha, G., Elgamal, Z., Kaiser, R., ... & Geraghty, P. (2020). Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics. Respiratory Research, 21(1), 1-17.

Ni, H., Xu, S., Chen, H., & Dai, Q. (2020). Nicotine modulates CTSS (cathepsin S) synthesis and secretion through regulating the autophagy-lysosomal machinery in atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 40(9), 2054-2069.

Lai, C. H., Chang, J. Y., Wang, K. C., Lee, F. T., Wu, H. L., & Cheng, T. L. (2020). Pharmacological inhibition of cathepsin S suppresses abdominal aortic aneurysm in mice. European Journal of Vascular and Endovascular Surgery, 59(6), 990-999.

Doherty, D. F., Nath, S., Poon, J., Foronjy, R. F., Ohlmeyer, M., Dabo, A. J., ... & Geraghty, P. (2019). Protein phosphatase 2A reduces cigarette smoke–induced cathepsin S and loss of lung function. American journal of respiratory and critical care medicine, 200(1), 51-62.

Kim, S., Jin, H., Seo, H. R., Lee, H. J., & Lee, Y. S. (2019). Regulating BRCA1 protein stability by cathepsin S-mediated ubiquitin degradation. Cell Death & Differentiation, 26(5), 812-825.

Wilkinson, R. D., Burden, R. E., McDowell, S. H., McArt, D. G., McQuaid, S., Bingham, V., ... & Scott, C. J. (2019). A novel role for cathepsin S as a potential biomarker in triple negative breast cancer. Journal of Oncology, 2019.

Edman, M. C., Janga, S. R., Meng, Z., Bechtold, M., Chen, A. F., Kim, C., ... & Hamm-Alvarez, S. F. (2018). Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients. Scientific reports, 8(1), 1-12.

Tan, J., Qian, X., Song, B., An, X., Cai, T., Zuo, Z., ... & Li, H. (2018). Integrated bioinformatics analysis reveals that the expression of cathepsin S is associated with lymph node metastasis and poor prognosis in papillary thyroid cancer. Oncology reports, 40(1), 111-122.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant CTSS protein, His Tag (CAT#: V2LY-0526-LY7927)

Rat Recombinant CTSS protein, His Tag (CAT#: V2LY-0526-LY9201)

Human CTSS ELISA Kit (CAT#: V2LY-0626-LY1105)

Rat Ctss ELISA Kit (CAT#: V2LY-0626-LY2113)

Mouse Ctss ELISA Kit (CAT#: V2LY-0626-LY2134)

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Isotype control

For research use only. Not intended for any clinical use.

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