Human Recombinant CXCL5 protein (V2LY-0526-LY3437)

Name: Human Recombinant CXCL5 protein
SKU: V2LY-0526-LY3437
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant CXCL5 protein consist of Amino Acid: 45-114 and predicts a molecular mass of 7.8 kDa.

Molecule Mass

7.8 kDa

Sequence

Amino Acid: 45-114

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

C-X-C Motif Chemokine Ligand 5

Function

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes.

Biological Process

Antimicrobial humoral immune response mediated by antimicrobial peptide Source: GO_Central
Cell-cell signaling Source: ProtInc
Cellular response to lipopolysaccharide Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Inflammatory response Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell population proliferation Source: ProtInc
Signal transduction Source: ProtInc

Cellular Location

Secreted

PTM

N-terminal processed forms ENA-78(8-78) and ENA-78(9-78) are produced by proteolytic cleavage after secretion from peripheral blood monocytes.

Kalchiem-Dekel, O., Yao, X., Barochia, A. V., Kaler, M., Figueroa, D. M., Karkowsky, W. B., ... & Levine, S. J. (2020). Apolipoprotein E signals via TLR4 to induce CXCL5 secretion by asthmatic airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology, 63(2), 185-197.

Bai, L., Yao, N., Qiao, G., Wu, L., & Ma, X. (2020). CXCL5 contributes to the tumorigenicity of cervical cancer and is post-transcriptionally regulated by miR-577. International Journal of Clinical and Experimental Pathology, 13(12), 2984.

Zhang, W., Wang, H., Sun, M., Deng, X., Wu, X., Ma, Y., ... & Miao, L. (2020). CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target. Cancer Communications, 40(2-3), 69-80.

Cui, D., Zhao, Y., & Xu, J. (2019). Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways. Cancer biology & therapy, 20(5), 608-616.

Wang, C. Y., Shang, M., Zhou, C. L., Feng, L. Z., Zhou, Q. S., & Hu, K. (2019). Mechanism of Cxc chemokine ligand 5 (CXCL5)/Cxc chemokine receptor 2 (CXCR2) bio-axis in mice with acute respiratory distress syndrome. Medical science monitor: international medical journal of experimental and clinical research, 25, 5299.

Lim, W. K., Chai, X., Ghosh, S., Ray, D., Wang, M., Rasheed, S. A. K., & Casey, P. J. (2019). Gα-13 induces CXC motif chemokine ligand 5 expression in prostate cancer cells by transactivating NF-κB. Journal of Biological Chemistry, 294(48), 18192-18206.

Wang, C., Li, A., Yang, S., Qiao, R., Zhu, X., & Zhang, J. (2018). CXCL5 promotes mitomycin C resistance in non-muscle invasive bladder cancer by activating EMT and NF-κB pathway. Biochemical and biophysical research communications, 498(4), 862-868.

O'Sullivan, S. A., O'Sullivan, C., Healy, L. M., Dev, K. K., & Sheridan, G. K. (2018). Sphingosine 1‐phosphate receptors regulate TLR 4‐induced CXCL 5 release from astrocytes and microglia. Journal of neurochemistry, 144(6), 736-747.

Zhao, Y., Zhang, X., Zhao, H., Wang, J., & Zhang, Q. (2018). CXCL5 secreted from adipose tissue‑derived stem cells promotes cancer cell proliferation. Oncology Letters, 15(2), 1403-1410.

Smith, K. J., Boyer, J. A., Muku, G. E., Murray, I. A., Gowda, K., Desai, D., ... & Perdew, G. H. (2017). Editor’s highlight: Ah receptor activation potentiates neutrophil chemoattractant (CXC motif) ligand 5 expression in keratinocytes and skin. Toxicological Sciences, 160(1), 83-94.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant CXCL5 protein, His Tag (CAT#: V2LY-0526-LY8180)

Human CXCL5 ELISA Kit (CAT#: V2LY-0626-LY434)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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