Human Recombinant ETF1 protein, GST Tag (V2LY-0526-LY3937)

Name: Human Recombinant ETF1 protein, GST Tag
SKU: V2LY-0526-LY3937
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant ETF1 protein, GST Tag consist of Amino Acid: 2-end and predicts a molecular mass of 74 kDa.

Molecule Mass

74 kDa

Sequence

Amino Acid: 2-end

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

eukaryotic translation termination factor 1

Research Area

Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (PubMed:7990965, PubMed:24486019).

Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes (PubMed:30682371).

Biological Process

Cytoplasmic translational termination Source: GO_Central
Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB-KW
Protein methylation Source: MGI
Regulation of translational termination Source: UniProtKB
Translational termination Source: MGI

Cellular Location

Cytoplasm

PTM

Methylated at Gln-185 by N6AMT1.
Hydroxylation at Lys-63 by JMJD4 promotes its translational termination efficiency.

Hu, A., Hong, F., Li, D., Xie, Q., Chen, K., Zhu, L., & He, H. (2022). KDM3B-ETF1 fusion gene downregulates LMO2 via the WNT/β-catenin signaling pathway, promoting metastasis of invasive ductal carcinoma. Cancer Gene Therapy, 29(2), 215-224.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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