Human Recombinant FCGR3B (NA2 allotype) protein, His Tag (V2LY-0526-LY2696)

Name: Human Recombinant FCGR3B (NA2 allotype) protein, His Tag
SKU: V2LY-0526-LY2696
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant FCGR3B (NA2 allotype) protein, His Tag consist of Amino Acid: 1-200 and predicts a molecular mass of 22.2 kDa.

Molecule Mass

22.2 kDa

Verified

HPLC

Sequence

Amino Acid: 1-200

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC. ≥90% as determined by SEC-MALS(Routinely tested).

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tirs, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Fc Fragment Of IgG Receptor IIIb

Research Area

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Biological Process

Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central

Cellular Location

Cell membrane; Secreted. Secreted after cleavage.

PTM

Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
The soluble form is produced by a proteolytic cleavage.

Alyasova, A. V., Amoev, Z. V., Shkola, O. O., Novikov, D. V., Selivanova, S. G., & Novikov, V. V. (2022). Messenger RNA of FCGR3A and FCGR3B Genes as Monitoring Markers of Clear Cell Renal Adenocarcinoma (a Pilot Study). Современные технологии в медицине, 14(3 (eng)), 22-26.

Ines, M., Moalla, M., Aicha, B. T., Selma, B., Leila, R., Rawdha, T., ... & Imen, S. (2022). Impact of FCGR2A R131h, FCGR3A F158V and FCGR3B NA1/NA2 Polymorphisms on Response to Fc-Containing TNF Inhibitor in Rheumatoid Arthritis. FCGR3A F158V and FCGR3B NA1/NA2 Polymorphisms on Response to Fc-Containing TNF Inhibitor in Rheumatoid Arthritis (3/28/2022).

Nassir, N., Tambi, R., Bankapur, A., Al Heialy, S., Karuvantevida, N., Khansaheb, H. H., ... & Uddin, M. (2021). Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19. Iscience, 24(9), 103030.

Alberici, F., Bonatti, F., Adorni, A., Daminelli, G., Sinico, R. A., Gregorini, G., ... & Vaglio, A. (2020). FCGR3B polymorphism predicts relapse risk in eosinophilic granulomatosis with polyangiitis. Rheumatology, 59(11), 3563-3566.

Dwomoh, D., Adu, B., Dodoo, D., Theisen, M., Iddi, S., & Gerds, T. A. (2020). Evaluating the predictive performance of malaria antibodies and FCGR3B gene polymorphisms on Plasmodium falciparum infection outcome: a prospective cohort study. Malaria Journal, 19(1), 1-12.

Kilani, B., Cornélis, F., Olaso, R., Chaudru, V., & Petit-Teixeira, E. (2019). Investigation of candidate gene copy number identifies FCGR3B as a potential biomarker for rheumatoid arthritis. Clinical and experimental rheumatology, 37(6), 923-928.

Dahmani, C. A., Benzaoui, A., Amroun, H., Zemani‐Fodil, F., Petit‐Teixeira, E., & Boudjema, A. (2019). Association study of copy number variants in CCL3L1, FCGR3A and FCGR3B genes with risk of ankylosing spondylitis in a West Algerian population. International Journal of Immunogenetics, 46(6), 437-443.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant FCGR3B (NA1 allotype) protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2692)

Human Recombinant FCGR3B (NA1 allotype) protein, His Tag (CAT#: V2LY-0526-LY2693)

Human Recombinant FCGR3B (NA2 allotype) protein, His & AVI Tag (CAT#: V2LY-0526-LY2694)

Human Recombinant FCGR3B (NA2 allotype) protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2695)

Human Recombinant FCGR3B (NA2 allotype) protein, His Tag-1 (CAT#: V2LY-0526-LY2697)

Human Recombinant FCGR3B (SH allotype) protein, His Tag (CAT#: V2LY-0526-LY2698)

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Human Recombinant FCGR3B (NA2 allotype) protein, His Tag-1 (CAT#: V2LY-0526-LY2697)

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Human Recombinant FCGR3B (NA1 allotype) protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY2692)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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