FCGR3B
The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Full Name
Fc Fragment Of IgG Receptor IIIb
Research Area
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Biological Process
Cell surface receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Immune response Source: ProtInc
Regulation of immune response Source: GO_Central
Cellular Location
Cell membrane; Secreted. Secreted after cleavage.
PTM
Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.
The soluble form is produced by a proteolytic cleavage.
The soluble form is produced by a proteolytic cleavage.
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Anti-FCGR3B antibodies
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CompareTarget: FCGR3B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB212
Application*: IF, FC
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB231A
Application*: ELISA, WB
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB213
Application*: IF, FC
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB211
Application*: IF, FC
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB210
Application*: IF, FC
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB209
Application*: IF, FC
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0272-5L11
Application*: WB, F
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 1D3
Application*: FC
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 5L11
Application*: C, WB
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2774
Application*: F
Target: FCGR3B
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0887
Application*: F
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C2492
Application*: F, WB
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2697
Application*: P
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2696
Application*: E
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBXF-3575
Application*: F
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2590
Application*: F
Target: FCGR3B
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2589
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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