Human Recombinant FOLH1 protein, ECD, His Tag-2 (V2LY-0526-LY6378)

Name: Human Recombinant FOLH1 protein, ECD, His Tag-2
SKU: V2LY-0526-LY6378
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant FOLH1 protein, ECD, His Tag consist of Amino Acid: 44-750 and predicts a molecular mass of 81.86 kDa.

Molecule Mass

81.86 kDa

Protein Domain

ECD

Verified

HPLC

Sequence

Amino Acid: 44-750

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

<0.5 EU/mg protein.

Format

Liquid

Buffer

PBS, NaCl, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Glutamate carboxypeptidase 2

Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.

Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Biological Process

C-terminal protein deglutamylation Source: BHF-UCL
Proteolysis Source: BHF-UCL

Cellular Location

Cell membrane
Isoform PSMA': Cytoplasm

Topology

Cytoplasmic: 1-19
Helical: 20-43
Extracellular: 44-750

PTM

The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
The N-terminus is blocked.

Sun, D., Zhang, A., Gao, B., Zou, L., Huang, H., Zhao, X., & Xu, D. (2022). Identification of Alternative Splicing-Related Genes CYB561 and FOLH1 in the Tumor-Immune Microenvironment for Endometrial Cancer Based on TCGA Data Analysis. Frontiers in Genetics, 13.

Ramirez‐Fort, M. K., Meier‐Schiesser, B., Lachance, K., Mahase, S. S., Church, C. D., Niaz, M. J., ... & Bander, N. H. (2021). Folate hydrolase‐1 (FOLH1) is a novel target for antibody‐based brachytherapy in Merkel cell carcinoma. Skin health and disease, 1(1), e9.

Zink, C. F., Barker, P. B., Sawa, A., Weinberger, D. R., Wang, M., Quillian, H., ... & Bigos, K. L. (2020). Association of missense mutation in FOLH1 with decreased NAAG levels and impaired working memory circuitry and cognition. American Journal of Psychiatry, 177(12), 1129-1139.

Bahler, C. D., Johnson, M. M., Davicioni, E., Zhang, J., Cheng, L., Green, M. A., & Koch, M. O. (2020). Predictors of Prostate-specific Membrane Antigen (PSMA/FOLH1) Expression in a Genomic Database. Urology, 144, 117-122.

Kwan, E. M., To, S. Q., Fettke, H. C., Docanto, M. M., Bukczynska, P., Mant, A. M., ... & Azad, A. (2019). Whole blood FOLH1 mRNA expression and treatment response in metastatic castration-resistant prostate cancer (mCRPC).

Šilhavý, J., Marková, I., Hüttl, M., Malínská, H., Kazdová, L., Liška, F., ... & Oliyarnyk, O. (2018). Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats. Physiological research, 67(4), 657-662.

Paul, S., Sadhukhan, S., Munian, D., Bankura, B., & Das, M. (2018). Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India. Birth Defects Research, 110(14), 1129-1138.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant FOLH1 protein, His Tag (CAT#: V2LY-0526-LY1315)

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Human Recombinant FOLH1 protein, AF647 Conjugated, His Tag (CAT#: V2LY-0526-LY6372)

Human Recombinant FOLH1 protein, APC Conjugated, His Tag (CAT#: V2LY-0526-LY6373)

Human Recombinant FOLH1 protein, ECD, AVI & His Tag (CAT#: V2LY-0526-LY6374)

Human Recombinant FOLH1 protein, ECD, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY6375)

Human Recombinant FOLH1 protein, ECD, His Tag (CAT#: V2LY-0526-LY6376)

Human Recombinant FOLH1 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY6377)

Human Recombinant FOLH1 protein, PE Conjugated, His Tag (CAT#: V2LY-0526-LY6379)

Cynomolgus Recombinant FOLH1 protein, His Tag (CAT#: V2LY-0526-LY1627)

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Human Recombinant FOLH1 protein, ECD, His Tag (CAT#: V2LY-0526-LY6376)

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Human Recombinant FOLH1 protein, ECD, His Tag-1 (CAT#: V2LY-0526-LY6377)

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Cynomolgus Recombinant FOLH1 protein, His Tag (CAT#: V2LY-0526-LY1627)

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Isotype control

For research use only. Not intended for any clinical use.

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