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FOLH1

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]

Full Name

Glutamate carboxypeptidase 2

Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.

Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Biological Process

C-terminal protein deglutamylation Source: BHF-UCL
Proteolysis Source: BHF-UCL

Cellular Location

Cell membrane
Isoform PSMA': Cytoplasm

Topology

Cytoplasmic: 1-19
Helical: 20-43
Extracellular: 44-750

PTM

The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
The N-terminus is blocked.

Anti-FOLH1 antibodies

Rabbit Anti-FOLH1 Recombinant Antibody (CBXF-1053) (CBMAB-F2943-CQ)

SDS

Target: FOLH1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-1053

Application*: WB, IP, F

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0805) (CBMAB-F0451-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXF-0805

Application*: E

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0807) (CBMAB-F0452-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0807

Application*: E, WB

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0808) (CBMAB-F0453-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-0808

Application*: IH, WB

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-1276) (CBMAB-F2941-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-1276

Application*: WB, F

Rabbit Anti-FOLH1 Monoclonal Antibody (CBFYR-0023) (CBMAB-R0038-FY)

SDS

Target: FOLH1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYR-0023

Application*: ELISA

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-1632) (CBMAB-F4117-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-1632

Application*: E, IF, WB

Rabbit Anti-FOLH1 (C-term) Recombinant Antibody (SP29) (CBMAB-F2990-CQ)

SDS

Target: FOLH1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: SP29

Application*: P

Mouse Anti-FOLH1 Recombinant Antibody (3B5) (CBMAB-A3064-LY)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3B5

Application*: WB, E

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0804) (CBMAB-F2965-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0804

Application*: E, WB, IH

Mouse Anti-FOLH1 Recombinant Antibody (5C4) (CBMAB-F1268-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5C4

Application*: WB, P, F

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-2346) (CBMAB-F1517-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-2346

Application*: E, IH

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-3746) (CBMAB-F1544-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Dog, Rat, Monkey, Mouse

Clone: CBXF-3746

Application*: IF, WB

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-3747) (CBMAB-F1552-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBXF-3747

Application*: WB

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-2345) (CBMAB-F1852-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXF-2345

Application*: E

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-3767) (CBMAB-F2249-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-3767

Application*: IH

Mouse Anti-FOLH1 Recombinant Antibody (Y-PSMA1) (CBMAB-F2422-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: Y-PSMA1

Application*: E, IF, C, P, WB

Mouse Anti-FOLH1 (C-term) Recombinant Antibody (CBXF-0806) (CBMAB-F2424-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXF-0806

Application*: E, P, WB

Mouse Anti-FOLH1 Recombinant Antibody (3H5) (CBMAB-F2428-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3H5

Application*: F, IF, P, WB

Mouse Anti-FOLH1 Recombinant Antibody (5A9) (CBMAB-F2446-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5A9

Application*: F, P, WB

Mouse Anti-FOLH1 (AA 44-750) Recombinant Antibody (GCP-04) (CBMAB-F2565-CQ)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: GCP-04

Application*: P, WB

Mouse Anti-FOLH1 Recombinant Antibody (GCP-05) (CBMAB-G0099-LY)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: GCP-05

Application*: F

Mouse Anti-FOLH1 Recombinant Antibody (CBLG1-012) (CBMAB-G0100-LY)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-012

Application*: IP, F

Mouse Anti-FOLH1 Recombinant Antibody (107.1A4) (CBMAB-P0342-YC)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 107.1A4

Application*: E, P, C

Mouse Anti-FOLH1 Recombinant Antibody (B791M) (CBMAB-P0343-YC)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: B791M

Application*: E

Mouse Anti-FOLH1 Recombinant Antibody (F-2) (CBMAB-P0344-YC)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: F-2

Application*: WB, IP, IF, E

Mouse Anti-FOLH1 Recombinant Antibody (LNI-17) (CBMAB-P0348-YC)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: LNI-17

Application*: F

Mouse Anti-FOLH1 Recombinant Antibody (YPSMA-1) (CBMAB-P0349-YC)

SDS

Target: FOLH1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: YPSMA-1

Application*: WB, E, P, C, F, IC, IF

Mouse Anti-FOLH1 Recombinant Antibody (IHC656) (CBMAB-MA094-YC)

SDS

Target: FOLH1

Host: Mouse

Specificity: Human

Clone: IHC656

Application*: IH

Rabbit Anti-FOLH1 Recombinant Antibody (RM327) (CBMAB-BR180LY)

SDS

Target: FOLH1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: RM327

Application*: IHC, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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