FOLH1

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Full Name
Glutamate carboxypeptidase 2
Function
Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.

Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Biological Process
C-terminal protein deglutamylation Source: BHF-UCL
Proteolysis Source: BHF-UCL
Cellular Location
Cell membrane
Isoform PSMA': Cytoplasm
Topology
Cytoplasmic: 1-19
Helical: 20-43
Extracellular: 44-750
PTM
The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis.
The N-terminus is blocked.
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Anti-FOLH1 antibodies

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Alpaca Anti-FOLH1 Recombinant VHH Antibody (CBXF-1632) (CBMAB-F4117-CQ)

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Target: FOLH1
Host: Alpaca
Antibody Isotype: VHH
Specificity: Human
Clone: CBXF-1632
Application*: E
Datasheet SDS

Human Anti-FOLH1 Recombinant Antibody (4) (CBMAB-F2565-CQ)

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Target: FOLH1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: 4
Application*: F
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-2345) (CBMAB-F1852-CQ)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2345
Application*: WB, IF, P, E
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-3746) (CBMAB-F1544-CQ)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3746
Application*: WB, P
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBLG1-012) (CBMAB-G0100-LY)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-012
Application*: WB, P
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0806) (V2LY-0925-LY2567)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Pig, Dog
Clone: CBXF-0806
Application*: WB, IF, P, E, in vivo
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-3767) (V2LY-0925-LY2565)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-3767
Application*: E
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-3747) (V2LY-0925-LY2563)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3747
Application*: IF
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-2346) (V2LY-0925-LY2561)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Dog
Clone: CBXF-2346
Application*: IF, WB, IH
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0808) (V2LY-0925-LY2559)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXF-0808
Application*: WB, IP, IF, P
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0807) (V2LY-0925-LY2558)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-0807
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBXF-0805) (V2LY-0925-LY2557)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXF-0805
Application*: WB, IP, IF, P
Datasheet SDS

Rabbit Anti-FOLH1 Recombinant Antibody (
6B10) (V2LY-0725-LY986)

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Target: FOLH1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 6B10
Application*: E, IH
Datasheet SDS

Mouse Anti-FOLH1 Recombinant Antibody (CBT3954) (V2LY-0625-LY906)

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Target: FOLH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3954
Application*: WB, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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