Human Recombinant GIPR-VLP protein, His & AVI Tag (V2LY-0526-LY4314)

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Basic Information

Expressed Host
HEK293 Cells
Protein Species
Human
Tag
His & AVI Tag
Protein Construction
This product is Human Recombinant GIPR-VLP protein, His & AVI Tag consist of Amino Acid: 22-247, 252-421 and predicts a molecular mass of 57.59 kDa.
Molecule Mass
57.59 kDa
Sequence
Amino Acid: 22-247, 252-421
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin
Please contact us for more information.
Format
Liquid
Preservative
None
Storage
Samples are stable for up to twelve months from date of receipt at -70°C. Store it under sterile conditions at -70°C or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
More Infomation

Target

Full Name
Gastric Inhibitory Polypeptide Receptor
Function
This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Biological Process
Activation of adenylate cyclase activity Source: ProtInc
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: BHF-UCL
Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
Cell surface receptor signaling pathway Source: ProtInc
Desensitization of G protein-coupled receptor signaling pathway Source: Ensembl
Endocrine pancreas development Source: Ensembl
Gastric inhibitory peptide signaling pathway Source: BHF-UCL
Generation of precursor metabolites and energy Source: ProtInc
Positive regulation of cAMP-mediated signaling Source: Ensembl
Positive regulation of cytosolic calcium ion concentration Source: Ensembl
Positive regulation of insulin secretion Source: Ensembl
Regulation of insulin secretion Source: ParkinsonsUK-UCL
Response to axon injury Source: Ensembl
Response to calcium ion Source: Ensembl
Response to fatty acid Source: Ensembl
Response to glucose Source: Ensembl
Response to nutrient Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 22-138
Helical: 139-161
Cytoplasmic: 162-169
Helical: 170-189
Extracellular: 190-217
Helical: 218-242
Cytoplasmic: 243-254
Helical: 255-278
Extracellular: 279-293
Helical: 294-319
Cytoplasmic: 320-341
Helical: 342-362
Extracellular: 363-377
Helical: 378-398
Cytoplasmic: 399-466
PTM
N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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