Human Recombinant IL24 protein, His Tag-1 (V2LY-0526-LY4862)

Name: Human Recombinant IL24 protein, His Tag-1
SKU: V2LY-0526-LY4862
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant IL24 protein, His Tag consist of Amino Acid: 1-207 and predicts a molecular mass of 19.5 kDa.

Molecule Mass

19.5 kDa

Verified

HPLC

Sequence

Amino Acid: 1-207

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

<5 EU/mg protein.

Format

Liquid

Buffer

Sodium phosphate, NaCl, Imidazole, PMSF, DTT, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 24

Function

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Biological Process

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-4IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Negative regulation of cell migrationIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinIEA:Ensembl
Serine phosphorylation of STAT proteinIEA:Ensembl
Wound healingIEA:Ensembl

Cellular Location

Secreted

PTM

Ubiquitination at Lys-122 promotes proteasomal degradation.

Sie, C., Kant, R., Peter, C., Muschaweckh, A., Pfaller, M., Nirschl, L., ... & Korn, T. (2022). IL-24 intrinsically regulates Th17 cell pathogenicity in mice. Journal of Experimental Medicine, 219(8), e20212443.

Feng, K. N., Meng, P., Zou, X. L., Zhang, M., Li, H. K., Yang, H. L., ... & Zhang, T. T. (2022). IL-37 protects against airway remodeling by reversing bronchial epithelial–mesenchymal transition via IL-24 signaling pathway in chronic asthma. Respiratory Research, 23(1), 1-17.

Davidson, S., Yu, C. H., Steiner, A., Ebstein, F., Baker, P. J., Jarur-Chamy, V., ... & Masters, S. L. (2022). Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24. Science Immunology, 7(68), eabi6763.

Chong, W. P., Mattapallil, M. J., Raychaudhuri, K., Bing, S. J., Wu, S., Zhong, Y., ... & Caspi, R. R. (2020). The cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24. Immunity, 53(2), 384-397.

Emdad, L., Bhoopathi, P., Talukdar, S., Pradhan, A. K., Sarkar, D., Wang, X. Y., ... & Fisher, P. B. (2020, November). Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic. In Seminars in cancer biology (Vol. 66, pp. 140-154). Academic Press.

Mitamura, Y., Nunomura, S., Furue, M., & Izuhara, K. (2020). IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases. Allergology International, 69(3), 405-411.

Schmetzer, O., Lakin, E., Topal, F. A., Preusse, P., Freier, D., Church, M. K., & Maurer, M. (2018). IL-24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria. Journal of Allergy and Clinical Immunology, 142(3), 876-882.

Mitamura, Y., Nunomura, S., Nanri, Y., Ogawa, M., Yoshihara, T., Masuoka, M., ... & Izuhara, K. (2018). The IL‐13/periostin/IL‐24 pathway causes epidermal barrier dysfunction in allergic skin inflammation. Allergy, 73(9), 1881-1891.

Menezes, M. E., Bhoopathi, P., Pradhan, A. K., Emdad, L., Das, S. K., Guo, C., ... & Fisher, P. B. (2018). Role of MDA-7/IL-24 a multifunction protein in human diseases. Advances in cancer research, 138, 143-182.

Pradhan, A. K., Bhoopathi, P., Talukdar, S., Shen, X. N., Emdad, L., Das, S. K., ... & Fisher, P. B. (2018). Recombinant MDA-7/IL24 suppresses prostate cancer bone metastasis through downregulation of the Akt/Mcl-1 pathway. Molecular cancer therapeutics, 17(9), 1951-1960.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IL24 protein, His Tag (CAT#: V2LY-0526-LY4861)

Human Recombinant IL24 protein, Fc Tag (CAT#: V2LY-0526-LY4863)

Human Recombinant IL24 protein, Fc Tag-1 (CAT#: V2LY-0526-LY4864)

Rat Il24 ELISA Kit (CAT#: V2LY-0626-LY1653)

Human IL24 ELISA Kit (CAT#: V2LY-0626-LY2448)

Mouse Il24 ELISA Kit (CAT#: V2LY-0626-LY5864)

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Mouse Il24 ELISA Kit (CAT#: V2LY-0626-LY5864)

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Human IL24 ELISA Kit (CAT#: V2LY-0626-LY2448)

Human Recombinant IL24 protein, Fc Tag (CAT#: V2LY-0526-LY4863)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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