IL24

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 24
Function
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-4IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Negative regulation of cell migrationIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinIEA:Ensembl
Serine phosphorylation of STAT proteinIEA:Ensembl
Wound healingIEA:Ensembl
Cellular Location
Secreted
PTM
Ubiquitination at Lys-122 promotes proteasomal degradation.
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Anti-IL24 antibodies

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Mouse Anti-IL24 Recombinant Antibody (4B6) (CBMAB-A4398-LY)

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Target: IL24
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B6
Application*: SE, E
Datasheet SDS

Mouse Anti-IL24 Recombinant Antibody (CBYY-I1196) (CBMAB-I2365-YY)

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Target: IL24
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1196
Application*: WB
Datasheet SDS

Mouse Anti-IL24 Recombinant Antibody (CBYY-I0889) (CBMAB-I2057-YY)

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Target: IL24
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0889
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-IL24 Recombinant Antibody (B-C60) (CBMAB-I1981-YY)

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Target: IL24
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: B-C60
Application*: FN, E
Datasheet SDS

Mouse Anti-IL24 Recombinant Antibody (B-C51) (CBMAB-I1977-YY)

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Target: IL24
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: B-C51
Application*: FN, E
Datasheet SDS

Mouse Anti-IL24 Recombinant Antibody (CBYY-I0191) (CBMAB-I0517-YY)

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Target: IL24
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0191
Application*: E
Datasheet SDS

Human Recombinant IL24 protein, Fc Tag-1 (V2LY-0526-LY4864)

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Target: IL24
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-207
Tag: Fc Tag
In Vivo Assay
Datasheet SDS

Human Recombinant IL24 protein, Fc Tag (V2LY-0526-LY4863)

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Target: IL24
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-207
Tag: Fc Tag
Datasheet SDS

Human Recombinant IL24 protein, His Tag-1 (V2LY-0526-LY4862)

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Target: IL24
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-207
Tag: His Tag
In Vivo Assay
Datasheet SDS

Human Recombinant IL24 protein, His Tag (V2LY-0526-LY4861)

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Target: IL24
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-207
Tag: His Tag
Datasheet SDS

Mouse Anti-IL24 Recombinant Antibody (A540) (CBMAB-AP3953LY)

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Target: IL24
Host: Mouse
Antibody Isotype: IgG
Specificity: Rat
Clone: A540
Application*: ICC, IHC, IP, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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