Human Recombinant IL31RA protein, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY4893)

Name: Human Recombinant IL31RA protein, Biotin Conjugated, His & AVI Tag
SKU: V2LY-0526-LY4893
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His & AVI Tag

Protein Construction

This product is Human Recombinant IL31RA protein, Biotin Conjugated, His & AVI Tag consist of Amino Acid: 1-516 and predicts a molecular mass of 58.6 kDa.

Molecule Mass

58.6 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 1-516

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 31 Receptor A

Function

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5 (PubMed:11877449, PubMed:14504285, PubMed:15627637, PubMed:15194700).
May function in skin immunity (PubMed:15184896).
Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (By similarity).
Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (By similarity).

Biological Process

Acute inflammatory response to antigenic stimulusIEA:Ensembl
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response1 PublicationNAS:UniProtKB
Defense response to other organismIEA:Ensembl
Glandular epithelial cell differentiationIEA:Ensembl
Homeostatic process1 PublicationNAS:UniProtKB
Macrophage differentiation1 PublicationNAS:UniProtKB
MAPK cascade1 PublicationNAS:UniProtKB
Monocyte differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Negative regulation of apoptotic process1 PublicationNAS:UniProtKB
Negative regulation of macrophage activation1 PublicationNAS:UniProtKB
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIEP:UniProtKB
Receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIEP:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathway1 PublicationNAS:UniProtKB

Cellular Location

Cell membrane; Cell junction, synapse, presynaptic cell membrane; Cell projection, axon

Involvement in disease

Amyloidosis, primary localized cutaneous, 2 (PLCA2):
A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins.

Topology

Extracellular: 20-519
Helical: 520-540
Cytoplasmic: 541-732

PTM

N-glycosylated.

Alghamdi, M. A., Al-Eitan, L. N., Aljamal, H. A., Shati, A. A., & Alshehri, M. A. (2022). Genetic association of IL2RA, IL17RA, IL23R, and IL31RA single nucleotide polymorphisms with alopecia areata. Saudi Journal of Biological Sciences, 29(11), 103460.

Fassett, M. S., Braz, J. M., Castellanos, C. A., Schroeder, A. W., Sadeghi, M., Mar, D. J., ... & Ansel, K. (2021). LB722 IL-31/IL31RA negatively regulate IL-4 production and cutaneous M2-like macrophage accumulation. Journal of Investigative Dermatology, 141(9), B5-B5.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human IL31RA ELISA Kit (CAT#: V2LY-0626-LY4768)

IL31RA Matched Antibody Pair (633) (CAT#: APMAB-633LY)

Cynomolgus Recombinant IL31RA protein, hFc Tag (CAT#: V2LY-0526-LY1570)

Cynomolgus Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY1571)

Human Recombinant IL31RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4892)

Human Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY4894)

Human Recombinant IL31RA protein, His Tag-1 (CAT#: V2LY-0526-LY4895)

Mouse Recombinant IL31RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8535)

Mouse Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY8536)

Rabbit Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY9136)

Antibody Pairs

IL31RA Matched Antibody Pair (633) (CAT#: APMAB-633LY)

Related Products

Human Recombinant IL31RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY4892)

Rat Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY9477)

Cynomolgus Recombinant IL31RA protein, hFc Tag (CAT#: V2LY-0526-LY1570)

Human Recombinant IL31RA protein, His Tag-1 (CAT#: V2LY-0526-LY4895)

Human Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY4894)

Cynomolgus Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY1571)

Human IL31RA ELISA Kit (CAT#: V2LY-0626-LY4768)

Mouse Recombinant IL31RA protein, ECD, hFc Tag (CAT#: V2LY-0526-LY8535)

Mouse Recombinant IL31RA protein, His Tag (CAT#: V2LY-0526-LY8536)

Mouse Anti-IL31RA Recombinant Antibody (3A10) (CAT#: CBMAB-A4405-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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