Human Recombinant IL5 protein (V2LY-0526-LY4933)

Name: Human Recombinant IL5 protein
SKU: V2LY-0526-LY4933
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Protein Construction

This product is Human Recombinant IL5 protein consist of Amino Acid: 20-134 and predicts a molecular mass of 13.15 kDa.

Molecule Mass

13.15 kDa

Sequence

Amino Acid: 20-134

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Interleukin 5

Alternative Names

Interleukin 5

Function

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Biological Process

Cytokine-mediated signaling pathwayIEA:Ensembl
Immune responseIEA:InterPro
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of B cell proliferationIEA:Ensembl
Positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Positive regulation of eosinophil differentiationIEA:Ensembl
Positive regulation of immunoglobulin productionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB
Positive regulation of podosome assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Positive regulation of transcription, DNA-templatedIEA:Ensembl

Cellular Location

Secreted

Maglio, A., Vitale, C., Pelaia, C., D’Amato, M., Ciampo, L., Sferra, E., ... & Vatrella, A. (2023). Severe asthma remissions induced by biologics targeting IL5/IL5r: results from a multicenter real-life study. International Journal of Molecular Sciences, 24(3), 2455.

Van Hulst, G., Jorssen, J., Jacobs, N., Henket, M., Louis, R., Schleich, F., ... & Desmet, C. J. (2022). Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma. European Respiratory Journal, 59(3).

Mümmler, C., Suhling, H., Walter, J., Kneidinger, N., Buhl, R., Kayser, M. Z., ... & Milger, K. (2022). Overall Response to Anti-IL-5/Anti-IL5-Rα Treatment in Severe Asthma Does Not Depend on Initial Bronchodilator Responsiveness. The Journal of Allergy and Clinical Immunology: In Practice, 10(12), 3174-3183.

Pala, D., & Pistis, M. (2021). Anti-IL5 drugs in COVID-19 patients: role of eosinophils in SARS-CoV-2-induced immunopathology. Frontiers in pharmacology, 12, 622554.

Bjerrum, A. S., Skjold, T., & Schmid, J. M. (2021). Oral corticosteroid sparing effects of anti-IL5/anti-IL5 receptor treatment after 2 years of treatment. Respiratory Medicine, 176, 106260.

Martínez-Moragón, E., García-Moguel, I., Nuevo, J., & Resler, G. (2021). Real-world study in severe eosinophilic asthma patients refractory to anti-IL5 biological agents treated with benralizumab in Spain (ORBE study). BMC Pulmonary Medicine, 21(1), 1-12.

Menzella, F., Ruggiero, P., Ghidoni, G., Fontana, M., Bagnasco, D., Livrieri, F., ... & Facciolongo, N. (2020). Anti-IL5 therapies for severe eosinophilic asthma: literature review and practical insights. Journal of Asthma and Allergy, 301-313.

Rademacher, J., Konwert, S., Fuge, J., Dettmer, S., Welte, T., & Ringshausen, F. C. (2020). Anti-IL5 and anti-IL5Rα therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series. European Respiratory Journal, 55(1).

Marc-Malovrh, M., Camlek, L., Škrgat, S., Kern, I., Fležar, M., Dežman, M., & Korošec, P. (2020). Elevated eosinophils, IL5 and IL8 in induced sputum in asthma patients with accelerated FEV1 decline. Respiratory Medicine, 162, 105875.

Ramonell, R. P., & Iftikhar, I. H. (2020). Effect of anti-IL5, anti-IL5R, anti-IL13 therapy on asthma exacerbations: a network meta-analysis. Lung, 198, 95-103.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Canine Recombinant IL5 protein, His Tag (CAT#: V2LY-0526-LY1288)

Cynomolgus Recombinant IL5 protein, His Tag (CAT#: V2LY-0526-LY1578)

Human Recombinant IL5 protein-1 (CAT#: V2LY-0526-LY4934)

Human Recombinant IL5 protein, Biotin Conjugated, His & AVI Tag (CAT#: V2LY-0526-LY4935)

Human Recombinant IL5 protein, His Tag (CAT#: V2LY-0526-LY4936)

Human Recombinant IL5 protein, Fc Tag (CAT#: V2LY-0526-LY4937)

Mouse Recombinant IL5 protein, His Tag (CAT#: V2LY-0526-LY8549)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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