Sign in or Register   Sign in or Register
  |  

IL5

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Full Name
Interleukin 5
Function
Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Biological Process
Cytokine-mediated signaling pathwayIEA:Ensembl
Immune responseIEA:InterPro
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of B cell proliferationIEA:Ensembl
Positive regulation of DNA-binding transcription factor activityIEA:Ensembl
Positive regulation of eosinophil differentiationIEA:Ensembl
Positive regulation of immunoglobulin productionIEA:Ensembl
Positive regulation of peptidyl-tyrosine phosphorylationISS:UniProtKB
Positive regulation of podosome assemblyManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Positive regulation of transcription, DNA-templatedIEA:Ensembl
Cellular Location
Secreted

Anti-IL5 antibodies

Loading...
Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Guinea pig, Human, Mouse
Clone: CBYY-I1134
Application*: E, F, WB
Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: CBYY-I1108
Application*: ED
Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1040
Application*: IH, WB
Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9906
Application*: WB, IS, IC, MC
Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0800
Application*: E, F, IH, WB
Target: IL5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cat
Clone: CBYY-I0678
Application*: N, EC
Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYY-I0669
Application*: E
Target: IL5
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBYY-I0668
Application*: E, F, IF, N, WB
Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I0651
Application*: E, F, IF, WB
Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I0650
Application*: E
Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5A10
Application*: E, WB
Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I0477
Application*: N, E
Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: TRFK5
Application*: E, ES, IS, IH, N, WB, MC, MC, FN
Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: TRFK4
Application*: E, I, WB, N
Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: JES1-5A10
Application*: EC, ED, ES, F
Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: JES1-39D10
Application*: E, IF, WB, ED, F, C, IC
Target: IL5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: 299298
Application*: IC, IF, N
Target: IL5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: CBYY-I0227
Application*: N
Target: IL5
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0023
Application*: E, EC, ED
Target: IL5
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Human, Monkey
Clone: CBYY-I0005
Application*: IS
Target: IL5
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYY-I0003
Application*: F, BL, N, MC
Target: IL5
Host: Rat
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: TRFK5
Application*: N
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare