Human Recombinant MMP19 protein (V2LY-0526-LY5614)

Name: Human Recombinant MMP19 protein
SKU: V2LY-0526-LY5614
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

E. coli

Protein Species

Human

Protein Construction

This product is Human Recombinant MMP19 protein consist of Amino Acid: 101-256 and predicts a molecular mass of 17.6 kDa.

Molecule Mass

17.6 kDa

Sequence

Amino Acid: 101-256

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>85% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

matrix metalloproteinase-19 isoform X2

Function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

Biological Process

Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Luteolysis Source: Ensembl
Ovarian follicle development Source: Ensembl
Ovulation from ovarian follicle Source: Ensembl
Proteolysis Source: UniProtKB
Response to cAMP Source: Ensembl
Response to hormone Source: Ensembl

Cellular Location

Extracellular matrix

Involvement in disease

Cavitary optic disc anomalies (CODA):
An ocular disease characterized by a profound excavation of the optic nerve. Clinical phenotype is variable and includes congenitally excavated optic nerves as well as other features of optic pit, optic nerve coloboma, and morning glory disk anomaly. Patients with CODA have a strong predilection for retinal detachment and/or separation of the retinal layers (retinoschisis) that lead to profound central vision loss.

PTM

Activated by autolytic cleavage after Lys-97.
Tyrosine phosphorylated by PKDCC/VLK.

Chen, Z., Wu, G., Ye, F., Chen, G., Fan, Q., Dong, H., ... & Wu, C. (2019). High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer. Bmc Cancer, 19(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Mmp19 ELISA Kit (CAT#: V2LY-0626-LY2610)

Human MMP19 ELISA Kit (CAT#: V2LY-0626-LY4868)

Related Products

Mouse Anti-MMP19 Recombinant Antibody (CBCNM-026) (CAT#: CBMAB-R0586-CN)

Mouse Mmp19 ELISA Kit (CAT#: V2LY-0626-LY2610)

Human MMP19 ELISA Kit (CAT#: V2LY-0626-LY4868)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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