Mouse Anti-MMP19 Recombinant Antibody (CBCNM-026) (CBMAB-R0586-CN)

Name: Mouse Anti-MMP19 Recombinant Antibody (CBCNM-026)
SKU: CBMAB-R0586-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBCNM-026

Application

WB, ICC, IHC-P, IHC-Fr, ELISA

Immunogen

Matrix Metalloproteinase 19

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.02% Sodium azide

Concentration

0.5 mg/mL

More Infomation

Target

Full Name

matrix metalloproteinase-19 isoform X2

Introduction

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

Entrez Gene ID

4327

UniProt ID

Q99542

Alternative Names

Matrix Metallopeptidase 19; Matrix Metalloproteinase RASI; Matrix Metalloproteinase-18; MMP18; Matrix Metalloproteinase-Beta19; Matrix Metalloproteinase 19; Matrix Metalloproteinase-19;

Function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

Biological Process

Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Luteolysis Source: Ensembl
Ovarian follicle development Source: Ensembl
Ovulation from ovarian follicle Source: Ensembl
Proteolysis Source: UniProtKB
Response to cAMP Source: Ensembl
Response to hormone Source: Ensembl

Cellular Location

Extracellular matrix

Involvement in disease

Cavitary optic disc anomalies (CODA):
An ocular disease characterized by a profound excavation of the optic nerve. Clinical phenotype is variable and includes congenitally excavated optic nerves as well as other features of optic pit, optic nerve coloboma, and morning glory disk anomaly. Patients with CODA have a strong predilection for retinal detachment and/or separation of the retinal layers (retinoschisis) that lead to profound central vision loss.

PTM

Activated by autolytic cleavage after Lys-97.
Tyrosine phosphorylated by PKDCC/VLK.

Chen, Z., Wu, G., Ye, F., Chen, G., Fan, Q., Dong, H., ... & Wu, C. (2019). High expression of MMP19 is associated with poor prognosis in patients with colorectal cancer. Bmc Cancer, 19(1), 1-9.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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