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Mouse Anti-MMP19 Recombinant Antibody (CBCNM-026) (CBMAB-R0586-CN)

This product is a Mouse antibody that recognizes MMP19. The antibody CBCNM-026 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all MMP19 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNM-026
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Matrix Metalloproteinase 19
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
matrix metalloproteinase-19 isoform X2
Introduction
This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Entrez Gene ID
4327
UniProt ID
Q99542
Alternative Names
Matrix Metallopeptidase 19; Matrix Metalloproteinase RASI; Matrix Metalloproteinase-18; MMP18; Matrix Metalloproteinase-Beta19; Matrix Metalloproteinase 19; Matrix Metalloproteinase-19;
Function
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.
Biological Process
Angiogenesis Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Collagen catabolic process Source: GO_Central
Extracellular matrix disassembly Source: Reactome
Extracellular matrix organization Source: GO_Central
Luteolysis Source: Ensembl
Ovarian follicle development Source: Ensembl
Ovulation from ovarian follicle Source: Ensembl
Proteolysis Source: UniProtKB
Response to cAMP Source: Ensembl
Response to hormone Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Cavitary optic disc anomalies (CODA):
An ocular disease characterized by a profound excavation of the optic nerve. Clinical phenotype is variable and includes congenitally excavated optic nerves as well as other features of optic pit, optic nerve coloboma, and morning glory disk anomaly. Patients with CODA have a strong predilection for retinal detachment and/or separation of the retinal layers (retinoschisis) that lead to profound central vision loss.
PTM
Activated by autolytic cleavage after Lys-97.
Tyrosine phosphorylated by PKDCC/VLK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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