Human Recombinant NEU2 protein, His Tag (V2LY-0526-LY5750)

Name: Human Recombinant NEU2 protein, His Tag
SKU: V2LY-0526-LY5750
Rating: 5 (1 reviews)

See all NEU2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant NEU2 protein, His Tag consist of Amino Acid: 1-380 and predicts a molecular mass of 43.7 kDa.

Molecule Mass

43.7 kDa

Sequence

Amino Acid: 1-380

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

sialidase 2 (cytosolic sialidase)

Function

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546).

Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940).

Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed:14613940).

Biological Process

Cellular oligosaccharide catabolic process Source: CAFA
Ganglioside catabolic process Source: UniProtKB
Glycoprotein catabolic process Source: UniProtKB
Glycosphingolipid metabolic process Source: Reactome
Oligosaccharide catabolic process Source: UniProtKB

Cellular Location

Cytosol

Li, Z., Wu, N., Wang, J., Yue, Y., Geng, L., & Zhang, Q. (2023). Low molecular weight fucoidan (LMWF) restores diabetic endothelial glycocalyx by targeting Neuraminidase2 (NEU2): a new therapy target in glycocalyx shedding. British Journal of Pharmacology.

van der Wal, D. E., Davis, A. M., Mach, M., & Marks, D. C. (2020). The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation. Haematologica, 105(4), 1081.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Human Recombinant NEU2 protein, His Tag?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human NEU2 ELISA Kit (CAT#: V2LY-0626-LY3643)

Related Products

Mouse Anti-NEU2 Recombinant Antibody (8C12) (CAT#: CBMAB-N2026-WJ)

Mouse Anti-NEU2 Recombinant Antibody (4F4) (CAT#: CBMAB-N2024-WJ)

Mouse Anti-NEU2 Recombinant Antibody (3G9) (CAT#: CBMAB-N2023-WJ)

Mouse Anti-NEU2 Recombinant Antibody (3B9) (CAT#: CBMAB-N2022-WJ)

Mouse Anti-NEU2 Recombinant Antibody (5E1) (CAT#: CBMAB-N2020-WJ)

Human NEU2 ELISA Kit (CAT#: V2LY-0626-LY3643)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry