NEU2

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq]
Full Name
sialidase 2 (cytosolic sialidase)
Function
Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides (PubMed:14613940, PubMed:22228546).

Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940).

Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed:14613940).
Biological Process
Cellular oligosaccharide catabolic process Source: CAFA
Ganglioside catabolic process Source: UniProtKB
Glycoprotein catabolic process Source: UniProtKB
Glycosphingolipid metabolic process Source: Reactome
Oligosaccharide catabolic process Source: UniProtKB
Cellular Location
Cytosol
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Anti-NEU2 antibodies

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Mouse Anti-NEU2 Recombinant Antibody (8C12) (CBMAB-N2026-WJ)

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Target: NEU2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 8C12
Application*: WB
Datasheet SDS

Mouse Anti-NEU2 Recombinant Antibody (4F4) (CBMAB-N2024-WJ)

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Target: NEU2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4F4
Application*: WB, F, IF
Datasheet SDS

Mouse Anti-NEU2 Recombinant Antibody (3G9) (CBMAB-N2023-WJ)

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Target: NEU2
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 3G9
Application*: E
Datasheet SDS

Mouse Anti-NEU2 Recombinant Antibody (3B9) (CBMAB-N2022-WJ)

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Target: NEU2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B9
Application*: E, WB
Datasheet SDS

Mouse Anti-NEU2 Recombinant Antibody (5E1) (CBMAB-N2020-WJ)

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Target: NEU2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5E1
Application*: WB, IF
Datasheet SDS

Human NEU2 ELISA Kit (V2LY-0626-LY3643)

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Target: NEU2
Sensitivity: 0.026 ng/mL
Detection Range: 0.05-30 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant NEU2 protein, His Tag (V2LY-0526-LY5750)

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Target: NEU2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-380
Tag: His Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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